Thèse de doctorat : Université de Fribourg, 2000 ; no 1284.
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Thèse de doctorat : Université de Fribourg, 2003 ; no 1409.
The oncogenic transcription factors E2F and Myc bind to specific DNA sequences at distinct times during the G1 phase of the mammalian cell cycle, and regulate transcription of a plethora of target genes. E2F and Myc associate with TRRAP, a subunit of distinct macromolecular complexes that contain the histone acetyltransferases (HATs) Gcn5/PCAF or Tip60. During the course of my thesis I...
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Thèse de doctorat : Université de Fribourg, 2002 ; Nr. 1396.
To cope with the daily changes in their environment, in organisms, from cyanobacteria to humans, endogenous clocks have evolved that anticipate these changes and synchronize physiology and behavior accordingly. In mammals, the central circadian pacemaker is located in the suprachiasmatic nuclei (SCN) of the hypothalamus. From there subordinated cellular clocks in the peripheral organs are...
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Thèse de doctorat : Université de Fribourg, 2002 ; no 1393.
This dissertation addresses three fundamental problems, which have to be handled in application domains like ubiquitous computing and Web services. The three problems heterogeneity, static configuration, and dynamic configuration are not only considered to persist during the near future but to increase, as similar application domains will emerge. The heterogeneity problem is defined and examples...
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Thèse de doctorat : Université de Fribourg, 1999 ; no 1272.
This thesis introduces a methodological approach to artificial agent design. In an attempt to solve the symbol grounding problem of artificial intelligence, a new theoretical perspective on the agent-environment relation is explored and experimentation is led to motivate this methodology. From the original idea that in order to ground an agent in an environment, the agent’s representation...
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Thèse de doctorat : Université de Fribourg, 2002 ; no 1392.
The future multi-layer optical networks based on wavelength division multiplexing technology will lead to the creation of new value-added optical services, which is bound to transform the traditional passive transport network into an active and intelligent transport layer. The successful deployment of these complex networking services and the possibility of subjecting them to a dynamic control,...
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Thèse de doctorat : Université de Fribourg, 2000 ; nr. 1321.
Apoptosis is a key event occurring in living organisms. In order to maintain tissue homeostasis, a comparable number of cells have to die to compensate for the cells produced by mitosis. However in many diseases this mechanism is altered. Once a malignancy is established, the conventional approach is to treat cells with drugs able to induce apoptosis. Although the execution of apoptosis is a...
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Thèse de doctorat : Université de Fribourg, 2000 ; no 1307.
Tenascin-R (TN-R) is a glycosylated brain extracellular matrix protein (BECM; Zamze et al., 1999) restricted to the central nervous system (Pesheva et al., 1989; Rathjen et al., 1991; Weber et al., 1999). A special feature of TN-R, and some of its known ligands, is their accumulation around certain sub-populations of neurones, forming perineuronal nets of extracellular matrix (PNEMs; Wintergerst...
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Thèse de doctorat : Université de Fribourg : 2001 ; 1340.
Uncertain knowledge can be represented in the framework of argumentation systems. In this framework, uncertainty is expressed using so-called assumptions. Depending on the setting of the assumptions, a given hypothesis of interest can be proved or falsified. The main goal of assumption-based reasoning is to determine the set of all supporting arguments for a given hypothesis. Such a supporting...
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Thèse de doctorat : Université de Fribourg : 2000 ; no 1312.
This thesis addresses the question of content-based image retrieval (CBIR) in heterogeneous databases. In an analysis of the existing CBIR tools that was done at the beginning of this work, we have shown that there was room for improvement in three key areas: query form, image and query representation, and computation of similarity. This analysis led us to studying the usability of a method for...
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