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Université de Neuchâtel

Probing the Active Site of Pseudomonas aeruginosa Porphobilinogen Synthase Using Newly Developed Inhibitors

Frère, Frederic ; Nentwich, Merle ; Gacond, Sabine ; Heinz, Dirk W. ; Neier, Reinhard ; Frankenberg-Dinkel, Nicole

In: Biochemistry, 2006, vol. 45, no. 27, p. 8243–8253

Porphobilinogen synthase catalyzes the first committed step of the tetrapyrrole biosynthesis pathway. In an aldol-like condensation, two molecules of 5-aminolevulinic acid (ALA) form the first pyrrole, porphobilinogen. Newly synthesized analogues of a reaction intermediate of porphobilinogen synthase have been employed in studying the active site and the catalytic mechanism of this early enzyme...

Université de Neuchâtel

Oxidation−Reduction and Activation Properties of Chloroplast Fructose 1,6-Bisphosphatase with Mutated Regulatory Site

Balmer, Yves ; Stritt-Etter, Anne-Lise ; Hirasawa, Masakazu ; Jacquot, Jean-Pierre ; Keryer, Eliane ; Knaff, David B. ; Schürmann, Peter

In: Biochemistry, 2001, vol. 40, no. 50, p. 15444–15450

The concentration of Mg2+ required for optimal activity of chloroplast fructose 1,6-bisphosphatase (FBPase) decreases when a disulfide, located on a flexible loop containing three conserved cysteines, is reduced by the ferredoxin/thioredoxin system. Mutation of either one of two regulatory cysteines in this loop (Cys155 and Cys174 in spinach FBPase) produces an enzyme with a...

Université de Neuchâtel

Compound-Specific Chlorine Isotope Analysis : A Comparison of Gas Chromatography/Isotope Ratio Mass Spectrometry and Gas Chromatography/Quadrupole Mass Spectrometry Methods in an Interlaboratory Study

Bernstein, A ; Shouakar-Stash, O ; Ebert, K ; Laskov, C ; Hunkeler, Daniel ; Jeannottat, Simon ; Sakaguchi-Söder, K ; Laaks, J ; Jochmann, M.A ; Cretnik, S ; Jager, J ; Haderlein, S.B ; Schmidt, T.C ; Aravena, R ; Elsner, M

In: Analytical Chemistry, 2011, vol. 83, p. 7624-7634

Chlorine isotope analysis of chlorinated hydrocarbons like trichloroethylene (TCE) is of emerging demand because these species are important environmental pollutants. Continuous flow analysis of noncombusted TCE molecules, either by gas chromatography/isotope ratio mass spectrometry (GC/IRMS) or by GC/quadrupole mass spectrometry (GC/qMS), was recently brought forward as innovative analytical...

Université de Neuchâtel

Synthesis, Molecular Structure, and Anticancer Activity of Cationic Arene Ruthenium Metallarectangles

Mattsson, Johan ; Govindaswamy, Padavattan ; Renfrew, Anna K. ; Dyson, Paul J. ; Štěpnička, Petr ; Süss-Fink, Georg ; Therrien, Bruno

In: Organometallics, 2009, vol. 28, no. 15, p. 4350–4357

The cytotoxicities of a new series of cationic metallarectangles have been established in the A2780 ovarian cancer cell line. Interestingly, the large rectangles incorporating 1,2-bis(4-pyridyl)ethylene linkers are ca. 5 times more cytotoxic (IC50 ≤ 6 μM) than the 4,4-bipyridine analogues (IC50 ≥ 30 μM), thus suggesting a correlation between cytotoxicity and the size...

Université de Neuchâtel

Template-Directed Synthesis of Hexanuclear Arene Ruthenium Complexes with Trigonal-Prismatic Architecture Based on 2,4,6-Tris(3-pyridyl)triazine Ligands

Freudenreich, Julien ; Furrer, Julien ; Süss-Fink, Georg ; Therrien, Bruno

In: Organometallics, 2011, vol. 30, no. 5, p. 942–951

Cationic arene ruthenium metalla-prisms of the general formula [Ru6(p-cymene)6(3-tpt)2(OO∩OO)3]6+ (3-tpt = 2,4,6-tris(3-pyridyl)-1,3,5-triazine; OO∩OO = 5,8-dioxido-1,4-naphthoquinonato [1]6+ or 6,11-dioxido-5,12-naphthacenedionato [2]6+) have been obtained from the corresponding...

Université de Neuchâtel

Switchable Mesomorphic Materials Based on the Ferrocene−Ferrocenium Redox System: Electron-Transfer-Generated Columnar Liquid-Crystalline Phases

Deschenaux, Robert ; Vilches, Maria-Teresa ; Schweissguth, Martin ; Levelut, Anne-Marie ; Long, Gary J. ; Hautot, Dimitri ; Luneau, Dominique

In: Organometallics, 1999, vol. 18, no. 26, p. 5553–5559

Oxidation of the non-mesomorphic ferrocene derivative 1 with silver toluene-4-sulfonate gave the ferrocenium derivative 2, which showed a monotropic columnar phase. The latter two-dimensional phase is composed of ribbons, in which derivative 2 is organized into bilayers, and has a centered rectangular symmetry with a = 318.3 Å and c = 94.9 Å. The Mössbauer...

Université de Neuchâtel

A Ferrocene-Containing Carbohydrate Surfactant: Thermotropic and Lyotropic Phase Behavior

Donnio, Bertrand ; Seddon, John M. ; Deschenaux, Robert

In: Organometallics, 2000, vol. 19, no. 16, p. 3077–3081

A ferrocene-containing carbohydrate surfactant has been synthesized and shown by polarized optical microscopy, differential scanning calorimetry, and X-ray diffraction to exhibit both thermotropic and lyotropic liquid-crystalline phase behavior. This new class of materials should prove useful for the design of redox-active lyotropic liquid crystals, allowing fine electrochemical control of the...

Université de Neuchâtel

Highly Efficient NMR Enantiodiscrimination of Chiral Octanuclear Metalla-Boxes in Polar Solvent

Barry, Nicolas P.E. ; Austeri, Martina ; Lacour, Jerôme ; Therrien, Bruno

In: Organometallics, 2009, vol. 28, no. 16, p. 4894–4897

Detection of the molecular chirality of a series of octanuclear metalla-boxes can be readily achieved using the NMR chiral solvating agent Λ-BINPHAT in CD3CN: only 0.05 to 0.10 equiv being necessary for a complete baseline separation of some of the proton signals.

Université de Neuchâtel

Adsorption of Phenolic Compounds from Aqueous Solutions, by Activated Carbons, Described by the Dubinin−Astakhov Equation

Stoeckli, Fritz ; López-Ramón, María Victoria ; Moreno-Castilla, Carlos

In: Langmuir, 2001, vol. 17, no. 11, p. 3301–3306

It is shown that the adsorption of phenol and 3-chlorophenol from aqueous solutions, by basic active carbons and at an equilibrium solution pH below that of dissociation of the phenols, can be described by an equation of the DRK type with exponent n = 4. The principle of temperature invariance is fulfilled between 283 and 313 K, which means that predictions can be made on the basis of a...