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Université de Neuchâtel

Working memory and semantic involvement in sentence processing: A case of pure progressive amnesia

Fossard, Marion ; Rigalleau, François ; Puel, Michèle ; Nespoulous, Jean-Luc ; Viallard, Gérard ; Démonet, Jean-François ; Cardebat, Dominique

In: Neuropsychologia, 2006, vol. 44, no. 3, p. 335-338

ED, a 83-year-old woman, meets the criteria of pure progressive amnesia, with gradual impairment of episodic and autobiographical memory, sparing of semantic processing and strong working memory (WM) deficit. The dissociation between disturbed WM and spared semantic processing permitted testing the role of WM in processing anaphors like pronouns or repeated names. Results showed a globally normal...

Université de Neuchâtel

Indirect anaphora in English and French: A cross-linguistic study of pronoun resolution

Cornish, Francis ; Garnham, Alan ; Cowles, H. Wind ; Fossard, Marion ; Andrée, Virginie

In: Journal of Memory and Language, 2005, vol. 52, no. 3, p. 363-376

There is disagreement within both linguistics and psycholinguistics concerning the use of unaccented third person pronouns to refer to implicit referents. Some researchers (e.g., Erkü & Gundel, 1987) argue that it is impossible or highly marked, while others (e.g., Yule, 1982) maintain that it is not only acceptable but commonly used in normal discourse. However, both sides in the debate may be...

Université de Fribourg

Surround inhibition in the primary motor cortex is task-specifically modulated in non-professional musicians but not in healthy controls during real piano playing

Márquez, Gonzalo ; Keller, Martin ; Lundbye-Jensen, Jesper ; Taube, Wolfgang

In: Neuroscience, 2018, vol. 373, p. 106–112

Research has indicated that at the onset of a finger movement, unwanted contractions of adjacent muscles are prevented by inhibiting the cortical areas representing these muscles. This so-called surround inhibition (SI) seems relevant for the performance of selective finger movements but may not be necessary for tasks involving functional coupling between different finger muscles. Therefore,...

Université de Fribourg

Age-related differences in cortical and subcortical activities during observation and motor imagery of dynamic postural tasks: an FMRI study

Mouthon, Audrey ; Ruffieux, Jan ; Mouthon, Michael ; Hoogewoud, Henri-Marcel ; Annoni, Jean-Marie ; Taube, Wolfgang

In: Neural Plasticity, 2018, p. -

Age-related changes in brain activation other than in the primary motor cortex are not well known with respect to dynamic balance control. Therefore, the current study aimed to explore age-related differences in the control of static and dynamic postural tasks using fMRI during mental simulation of balance tasks. For this purpose, 16 elderly (72 ± 5 years) and 16 young adults...

Université de Fribourg

Modulation of inhibitory control by prefrontal anodal tDCS: A crossover double-blind sham-controlled fMRI study

Sallard, Etienne ; Mouthon, Michael ; De Pretto, Michael ; Spierer, Lucas

In: PLOS ONE, 2018, vol. 13, no. 3, p. e0194936

Prefrontal anodal transcranial direct current stimulation (tDCS) has been proposed as a potential approach to improve inhibitory control performance. The functional consequences of tDCS during inhibition tasks remain, however, largely unresolved. We addressed this question by analyzing functional magnetic resonance imaging (fMRI) recorded while participants completed a Go/NoGo task after...

Université de Fribourg

17-β estradiol increases parvalbumin levels in Pvalb heterozygous mice and attenuates behavioral phenotypes with relevance to autism core symptoms

Filice, Federica ; Lauber, Emanuel ; Vörckel, Karl Jakob ; Wöhr, Markus ; Schwaller, Beat

In: Molecular Autism, 2018, vol. 9, p. 15

Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by two core symptoms: impaired social interaction and communication, and restricted, repetitive behaviors and interests. The pathophysiology of ASD is not yet fully understood, due to a plethora of genetic and environmental risk factors that might be associated with or causal for ASD. Recent findings...

Université de Fribourg

Biological noise and positional effects influence cell stemness

Blum, Walter ; Henzi, Thomas ; Schwaller, Beat ; Pecze, László

In: Journal of Biological Chemistry, 2018, vol. 293, no. 14, p. 5247–5258

Biological (or cellular) noise is the random quantitative variability of proteins and other molecules in individual, genetically identical cells. As the result of biological noise in the levels of some transcription factors that determine a cell's differentiation status, differentiated cells may dedifferentiate to a stem cell state given a sufficiently long time period. Here, to provide...

Université de Fribourg

Stress impacts the regulation neuropeptides in the rat hippocampus and prefrontal cortex

Li, Wenxue ; Papilloud, Aurelie ; Lozano-Montes, Laura ; Zhao, Nan ; Ye, Xueting ; Zhang, Xiaozhe ; Sandi, Carmen ; Rainer, Gregor

In: PROTEOMICS, 2018, vol. 18, no. 7, p. 1700408

Adverse life experiences increase the lifetime risk to several stress‐related psychopathologies, such as anxiety or depressive‐like symptoms following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully characterized. Neuropeptides play an important role as signaling molecules that contribute to physiological regulation and have been linked...