In: American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 2008, vol. 294, p. R730-R737
Brown, Clive M.; Division of Physiology, Department of Medicine, University of Fribourg, Switzerland Dulloo, Abdul G.; Division of Physiology, Department of Medicine, University of Fribourg, Switzerland Yepuri, Gayathri; Division of Physiology, Department of Medicine, University of Fribourg, Switzerland Montani, and Jean-Pierre; Division of Physiology, Department of Medicine, University of...
|
In: Faseb Journal, 2008, vol. 22, p. 774-785
Energy conservation directed at accelerating body fat recovery (or catch-up fat) contributes to obesity relapse after slimming and to excess fat gain during catch-up growth after malnutrition. To investigate the mechanisms underlying such thrifty metabolism for catch-up fat, we tested whether during refeeding after caloric restriction rats exhibiting catch-up fat driven by suppressed...
|
In: American Journal of Physiology: Heart and Circulatory Physiology, 2007, vol. 293, p. H1265-H1272
hereas the sympathetic nervous system has a well-established role in blood pressure (BP) regulation, it is not clear whether long-term levels of BP are affected by parasympathetic function or dysfunction. We tested the hypothesis that chronic blockade of the parasympathetic nervous system has sustained effects on BP, heart rate (HR), and BP variability (BPV). Sprague-Dawley rats were...
|
In: International Journal of Obesity, 2007, vol. 31, no. 2, p. 378–381
Mice lacking β-adrenoceptors, which mediate the thermogenic effects of norepinephrine and epinephrine, show diminished thermogenesis and high susceptibility to obesity, whereas mice lacking stearoyl-CoA desaturase 1 (SCD1), which catalyzes the synthesis of monounsaturated fatty acids, show enhanced thermogenesis and high resistance to obesity. In testing whether β-adrenergic...
|
In: International Journal of Obesity, 2007, vol. 31, no. 2, p. 201-203
|
In: British Journal of Nutrition, 2007, vol. 93, p. 417-419
|
In: American Journal of Physiology - Endocrinology and Metabolism, 2007, vol. 293, p. E91-E95
Glitazones are peroxisome proliferator-activated receptor (PPAR)-Γ agonists with powerful insulin-sensitizing properties. They promote the development of metabolically active adipocytes that can lead to a substantial gain in fat mass. Telmisartan is an ANG II type 1 receptor antagonist with partial PPAR-Γ agonistic properties. Recently, telmisartan has been reported to prevent weight gain and...
|
In: International Journal of Obesity, 2006, vol. 30, no. S4, p. S58–S66
In people trying to lose weight, there are often repeated cycles of weight loss and regain. Weight cycling is, however, not limited to obese adults but affects people of normal weight, particularly young women, who are unhappy with their appearance. Furthermore, the onset of a pattern of weight cycling is shifting towards younger ages, owing to the increasing prevalence of overweight and obesity...
|
In: International Journal of Obesity, 2006, vol. 30, no. S4, p. S23–S35
The analyses of large epidemiological databases have suggested that infants and children who show catch-up growth, or adiposity rebound at a younger age, are predisposed to the development of obesity, type 2 diabetes and cardiovascular diseases later in life. The pathophysiological mechanisms by which these growth trajectories confer increased risks for these diseases are obscure, but there is...
|
In: The FASEB Journal, 2006, vol. 20, no. 10, p. 1751-1753
An enhanced metabolic efficiency for accelerating the recovery of fat mass (or catch-up fat) is a characteristic feature of body weight regulation after weight loss or growth retardation and is the outcome of an "adipose-specific" suppression of thermogenesis, i.e., a feedback control system in which signals from the depleted adipose tissue fat stores exert a suppressive effect on thermogenesis....
|
