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Università della Svizzera italiana

Securing whistleblowing in the digital age : SecureDrop and the changing journalistic practices for source protection

Di Salvo, Philip

In: Digital Journalism, 2021, vol. 9, no. 4, p. 443-460

Information security tools have gained prominence and importance in the journalism field and are now being adopted more frequently by newsrooms and investigative journalists. SecureDrop, an opensource software for operating whistleblowing platforms, is now a common component of the toolboxes of journalists willing to work with stronger levels of security, especially in regard to source...

Università della Svizzera italiana

Exon–Intron differential analysis reveals the role of competing endogenous RNAs in post-transcriptional regulation of translation

Munz, Nicolas ; Cascione, Luciano ; Parmigiani, Luca ; Tarantelli, Chiara ; Rinaldi, Andrea ; Cmiljanovic, Natasa ; Cmiljanovic, Vladimir ; Giugno, Rosalba ; Bertoni, Francesco ; Napoli, Sara

In: Non-coding RNA, 2021, vol. 7, no. 2, p. 13

Stressful conditions induce the cell to save energy and activate a rescue program modulated by mammalian target of rapamycin (mTOR). Along with transcriptional and translational regulation, the cell relies also on post-transcriptional modulation to quickly adapt the translation of essential proteins. MicroRNAs play an important role in the regulation of protein translation, and their...

Università della Svizzera italiana

SARS-CoV-2 Ig G among HealthcareWorkers and the General Population

Milani, Gregorio P. ; Bianchetti, Mario G. ; Togni, Giuseppe ; Schoenenberger, Andreas W. ; Muggli, Franco

In: Pathogens, 2021, vol. 10, no. 4, p. 6

It is assumed that healthcare workers are at the highest risk to be infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, few data from healthcare workers who do not primarily take care of patients with SARS-CoV-2 infection support this assumption. We investigated the prevalence of immunoglobulin G (Ig G) against SARS-CoV-2 among healthcare workers who do not...

Università della Svizzera italiana

Inflation bald als Folgeeffekt der COVID-19-Pandemie? = Inflation soon a consequence of the COVID-19 pandemic?

Beretta, Edoardo

In: List Forum für Wirtschafts- und Finanzpolitik, 2021, vol. 46, no. 3, p. 359-377

Obwohl man im Zuge der COVID-19-Pandemie aufgrund des dramatischen Einbruchs aller Wirtschaftsprognosen weltweit bislang von rezessivdeflationären Auswirkungen ausgegangen ist, lassen sich Inflationsrisiken keineswegs ausschließen. Welche Folgeeffekte kann die Kombination aus milliardenhohen Liquiditätsspritzen bei starkem Produktionsrückgang sowie streng einzuhaltenden (und ebenso...

Università della Svizzera italiana

Electrolyte and acid-base disorders triggered by aminoglycoside or colistin therapy : a systematic review

Scoglio, Martin ; Bronz, Gabriel ; Rinoldi, Pietro O. ; Faré, Pietro B. ; Betti, Céline ; Bianchetti, Mario G. ; Simonetti, Giacomo D. ; Gennaro, Viola ; Renzi, Samuele ; Lava, Sebastiano A. G. ; Milani, Gregorio P.

In: Antibiotics, 2021, vol. 10, no. 2, p. 9

Aminoglycoside or colistin therapy may alter the renal tubular function without decreasing the glomerular filtration rate. This association has never been extensively investigated. We conducted a systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta- Analyses recommendations. Databases searched included United States National Library of...

Università della Svizzera italiana

Hard and soft EM in bayesian network learning from incomplete data

Ruggieri, Andrea ; Stranieri, Francesco ; Stella, Fabio ; Scutari, Marco

In: Algorithms, 2020, vol. 13, no. 12, p. 17

Incomplete data are a common feature in many domains, from clinical trials to industrial applications. Bayesian networks (BNs) are often used in these domains because of their graphical and causal interpretations. BN parameter learning from incomplete data is usually implemented with the Expectation-Maximisation algorithm (EM), which computes the relevant sufficient statistics (“soft EM”) ...

Università della Svizzera italiana

Pre-existing cardiovascular conditions as clinical predictors of myocarditis reporting with immune checkpoint inhibitors : a VigiBase study

Noseda, Roberta ; Ruinelli, Lorenzo ; van der Gaag, Linda C. ; Ceschi, Alessandro

In: Cancers, 2020, vol. 12, no. 11, p. 15

Up to 50% of myocarditis events developed in cancer patients upon treatment with immune checkpoint inhibitors (ICIs) are fatal. Therefore, identification of clinical risk factors predicting myocarditis onset during treatment with ICIs is important for the purpose of cardiac surveillance of high-risk patients. The aim of this retrospective matched case-control study was to assess whether...

Università della Svizzera italiana

6D virtual sensor for wrench estimation in robotized interaction tasks exploiting extended Kalman filter

Roveda, Loris ; Bussolan, Andrea ; Braghin, Francesco ; Piga, Dario

In: Machines, 2020, vol. 8, no. 4, p. 17

Industrial robots are commonly used to perform interaction tasks (such as assemblies or polishing), requiring the robot to be in contact with the surrounding environment. Such environments are (partially) unknown to the robot controller. Therefore, there is the need to implement interaction controllers capable of suitably reacting to the established contacts. Although standard force controllers...

Università della Svizzera italiana

Loss and revival of androgen receptor signaling in advanced prostate cancer

Formaggio, Nicolò ; Rubin, Mark A. ; Theurillat, Jean-Philippe

In: Oncogene, 2021, vol. 40, no. 7, p. 1205–1216

Targeting the androgen receptor (AR) signaling axis has been, over decades, the mainstay of prostate cancer therapy. More potent inhibitors of androgen synthesis and antiandrogens have emerged and have been successfully i mplemented in clinical practice. That said, the stronger inhibition of the AR signaling axis has led in recent years to an increase of prostate cancers that de-differentiate...

Università della Svizzera italiana

Impact of COVID-19 on the thyroid gland : an update

Scappaticcio, Lorenzo ; Pitoia, Fabián ; Esposito, Katherine ; Piccardo, Arnoldo ; Trimboli, Pierpaolo

In: Reviews in Endocrine and Metabolic Disorders, 2020, p. 13

Coronavirus disease 2019 (COVID-19) is the pandemic of the new millennium. COVID-19 can cause both pulmonary and systemic inflammation, potentially determining multi-organ dysfunction. Data on the relationship between COVID-19 and thyroid have been emerging, and rapidly increasing since March 2020. The thyroid gland and the virus infection with its associated inflammatory-immune responses are...