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Université de Fribourg

Acute endotoxemia in mice induces downregulation of megalin and cubilin in the kidney

Schreiber, Andrea ; Theilig, Franziska ; Schweda, Frank ; Höcherl, Klaus

In: Kidney International, 2012, p. -

Severe sepsis is often accompanied by acute renal failure with renal tubular dysfunction. Albuminuria is a common finding in septic patients and we studied whether it was due to an impairment of proximal tubular endocytosis of filtered albumin. We studied the regulation of megalin and cubilin, the two critical multiligand receptors responsible for albumin absorption, during severe experimental...

Consortium of Swiss Academic Libraries

Ageing as a determinant of renal and vascular disease: role of endothelial factors

Barton, Matthias

In: Nephrology Dialysis Transplantation, 2005, vol. 20, no. 3, p. 485-490

Université de Fribourg

A comparative study of different in vitro lung cell culture systems to assess the most beneficial tool for screening the potential adverse effects of carbon nanotubes

Clift, Martin J. D. ; Endes, Carola ; Vanhecke, Dimitri ; Wick, Peter ; Gehr, Peter ; Schins, Roel P. F. ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Toxicological Sciences, 2014, vol. 137, no. 1, p. 55-64

To determine the potential inhalatory risk posed by carbon nanotubes (CNTs), a tier-based approach beginning with an in vitro assessment must be adopted. The purpose of this study therefore was to compare 4 commonly used in vitro systems of the human lung (human blood monocyte-derived macrophages [MDM] and monocyte-derived dendritic cells [MDDC], 16HBE14o- epithelial cells, and...