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Università della Svizzera italiana

The antibody response to Plasmodium falciparum : cues for vaccine design and the discovery of receptor-based antibodies

Tan, Joshua ; Piccoli, Luca ; Lanzavecchia, Antonio

In: Annual Review of Immunology

P. falciparum remains a serious public health problem and a continuous challenge for the immune system due to the complexity and diversity of the pathogen. Recent advances from several laboratories in the characterization of the antibody response to the parasite have led to the identification of critical targets for protection and revealed a new mechanism of diversification based on the...

Université de Fribourg

The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities

Wider, Diana ; Péli-Gulli, Marie-Pierre ; Briand, Pierre-André ; Tatu, Utpal ; Picard, Didier

In: Molecular and Biochemical Parasitology, 2009, vol. 164, no. 2, p. 147-152

Developing novel drugs against the unicellular parasite Plasmodium is complicated by the paucity of simple screening systems. Heat-shock proteins are an essential class of proteins for the parasite's cyclical life style between different cellular milieus and temperatures. The molecular chaperone Hsp90 assists a large variety of proteins, but its supporting functions for many proteins that are...

Consortium of Swiss Academic Libraries

Current Challenges in Travelers' Malaria

Schlagenhauf, Patricia ; Petersen, Eskild

In: Current Infectious Disease Reports, 2013, vol. 15, no. 4, p. 307-315