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Université de Fribourg

In vivo over-expression of interleukin-10 increases resistance to focal brain ischemia in mice

Bilbao, Fabienne de ; Arsenijevic, Denis ; Moll, Thomas ; Garcia-Gabay, Irene ; Vallet, Philippe ; Langhans, Wolfgang ; Giannakopoulos, Panteleimon

In: Journal of Neurochemistry, 2009///doi: 10.1111/j.1471-4159.2009.06098.x

Early studies showed that the administration of the anti-inflammatory cytokine interleukin-10 (IL10) protects against permanent middle cerebral artery occlusion (MCAO) in mice. In this study, transgenic mice expressing murine IL10 (IL10T) directed by the major histocompatibility complex Ea promoter were produced and used to explore the effect of chronically increased IL10 levels on MCAO-related...

Université de Fribourg

TNF-α suppresses the expression of clock genes by interfering with E-box-mediated transcription

Cavadini, Gionata ; Petrzilka, Saskia ; Kohler, Philipp ; Jud, Corinne ; Tobler, Irene

In: Proceedings of the National Academy of Sciences of the United States of America, 2007, vol. 104, no. 31, p. 12843-12848

Production of TNF-α and IL-1 in infectious and autoimmune diseases is associated with fever, fatigue, and sleep disturbances, which are collectively referred to as sickness behavior syndrome. In mice TNF-α and IL-1 increase nonrapid eye movement sleep. Because clock genes regulate the circadian rhythm and thereby locomotor activity and may alter sleep architecture we assessed the influence of...