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Université de Fribourg

Impairment of acquisition of intravenous cocaine self-administration by RNA-interference of dopamine D1-receptors in the nucleus accumbens shell

Pisanu, Augusta ; Lecca, Daniele ; Valentini, Valentina ; Bahi, Amine ; Dreyer, Jean-Luc ; Cacciapaglia, Fabio ; Scifo, Andrea ; Piras, Giovanna ; Cadoni, Cristina ; Chiara, Gaetano Di

In: Neuropharmacology, 2015, vol. 89, p. 398–411

Microdialysis during i.v. drug self-administration (SA) have implicated nucleus accumbens (NAc) shell DA in cocaine and heroin reinforcement. However, this correlative evidence has not been yet substantiated by experimental evidence obtained by studying the effect of selective manipulation of NAc shell DA transmission on cocaine and heroin SA. In order to investigate this issue, DA D1a receptor...

Université de Fribourg

The role of tissue-type plasminogen activator system in amphetamine-induced conditional place preference extinction and reinstatement

Bahi, Amine ; Kusnecov, Alexander ; Dreyer, Jean-Luc

In: Neuropsychopharmacology, 2008, vol. 33, p. 2726–2734

Extracellular serine proteases of the plasminogen activator family (tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) may modulate synaptic adhesion and associate with learning behavior. Psychostimulants strongly induce their expression in the mesolimbic dopaminergic pathway, but cocaine preferentially induces uPA, whereas morphine and amphetamine...

Université de Neuchâtel

The impact of gene knock-down and vaccination against salivary metalloproteases on blood feeding and egg laying by Ixodes ricinus

Decrem, Yves ; Mariller, Marcel ; Lahaye, Kathia ; Blasioli, Virginie ; Beaufays, Jérôme ; Boudjeltia, Karim Zouaoui ; Vanhaeverbeek, Michel ; Cérutti, Martine ; Brossard, Michel ; Vanhamme, Luc ; Godfroid, Edmond

In: International Journal for Parasitology, 2008, vol. 38, no. 5, p. 549-560

Two cDNAs coding homologous putative metalloproteases (Metis 1 and Metis 2, expected molecular weights of 55.6 and 56.0 kDa, respectively) were identified from the hard tick Ixodes ricinus. The expression of Metis genes was induced in salivary glands during tick blood meal. RNA interference was used to assess the role of both Metis 1 and Metis 2 in tick feeding. It was found that salivary...