Université de Fribourg

A novel gene expression signature in peripheral blood mononuclear cells for early detection of colorectal cancer

Monaco, Alessandra ; Michelin, Olivier ; Prior, John ; Rüegg, Curzio ; Scapozza, Leonardo ; Seimbille, Yann

In: Alimentary Pharmacology & Therapeutics, 2014, vol. 39, no. 5, p. 507–517

Arginine–glycine–aspartic acid (RGD)-containing peptides have been traditionally used as PET probes to noninvasively image angiogenesis, but recently, small selective molecules for α₅β₁ integrin receptor have been developed with promising results. Sixty-one antagonists were screened, and tert-butyl...