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Live Virus Vaccines in Transplantation: Friend or Foe?

Verolet, Charlotte ; Posfay-Barbe, Klara

In: Current Infectious Disease Reports, 2015, vol. 17, no. 4, p. 1-11

Identification and structure of a multidonor class of head-directed influenza-neutralizing antibodies reveal the mechanism for its recurrent elicitation

Sao-Fong Cheung, Crystal ; Fruehwirth, Alexander ; Paparoditis, Philipp Carl Georg ; Shen, Chen-Hsiang ; Foglierini, Mathilde ; Joyce, M. Gordon ; Leung, Kwanyee ; Piccoli, Luca ; Rawi, Reda ; Silacci-Fregni, Chiara ; Tsybovsky, Yaroslav ; Verardi, Raffaello ; Wang, Lingshu ; Wang, Shuishu ; Yang, Eun Sung ; Zhang, Baoshan ; Zhang, Yi ; Chuang, Gwo-Yu ; Corti, Davide ; Mascola, John R. ; Shapiro, Lawrence ; Kwong, Peter D. ; Lanzavecchia, Antonio ; Zhou, Tongqing

In: Cell reports, 2020, vol. 32, no. 9, p. 12 p

Multidonor antibodies are of interest for vaccine design because they can in principle be elicited in the general population by a common set of immunogens. For influenza, multidonor antibodies have been observed against the hemagglutinin (HA) stem, but not the immunodominant HA head. Here, we identify and characterize a multidonor antibody class (LPAF-a class) targeting the HA head. This class...

Macrophage death following influenza vaccination initiates the inflammatory response that promotes dendritic cell function in the draining lymph node

Chatziandreou, Nikolaos ; Farsakoglu, Yagmur ; Palomino-Segura, Miguel ; D’Antuono, Rocco ; Pizzagalli, Diego Ulisse ; Sallusto, Federica ; Lukacs-Kornek, Veronika ; Uguccioni, Mariagrazia ; Corti, Davide ; Turley, Shannon J. ; Lanzavecchia, Antonio ; Carroll, Michael C. ; Gonzalez, Santiago F.

In: Cell reports, 2017, vol. 18, no. 10, p. 2427-2440

The mechanism by which inflammation influences the adaptive response to vaccines is not fully understood. Here, we examine the role of lymph node macrophages (LNMs) in the induction of the cytokine storm triggered by inactivated influenza virus vaccine. Following vaccination, LNMs undergo inflammasome-independent necrosis-like death that is reliant on MyD88 and Toll-like receptor 7 (TLR7)...

Computational docking of antibody-antigen complexes, opportunities and pitfalls illustrated by influenza hemagglutinin

Pedotti, Mattia ; Simonelli, Luca ; Livoti, Elsa ; Varani, Luca

In: International journal of molecular sciences, 2011, vol. 12, no. 1, p. 226-251

Antibodies play an increasingly important role in both basic research and the pharmaceutical industry. Since their efficiency depends, in ultimate analysis, on their atomic interactions with an antigen, studying such interactions is important to understand how they function and, in the long run, to design new molecules with desired properties. Computational docking, the process of predicting...

Influenza hemagglutinin membrane anchor

Benton, Donald J. ; Nans, Andrea ; Calder, Lesley J. ; Turner, Jack ; Neu, Ursula ; Lin, Yi Pu ; Ketelaars, Esther ; Kallewaard, Nicole L. ; Corti, Davide ; Lanzavecchia, Antonio ; Gamblin, Steven J. ; Rosenthal, Peter B. ; Skehel, John J.

In: Proceedings of the national academy of sciences of the United States of America, 2018, vol. 115, no. 40, p. 10112-10117

Viruses with membranes fuse them with cellular membranes, to transfer their genomes into cells at the beginning of infection. For Influenza virus, the membrane glycoprotein involved in fusion is the hemagglutinin (HA), the 3D structure of which is known from X-ray crystallographic studies. The soluble ectodomain fragments used in these studies lacked the “membrane anchor” portion of the...

Influenza in Travelers: Epidemiology, Risk, Prevention, and Control Issues

Steffen, Robert

In: Current Infectious Disease Reports, 2010, vol. 12, no. 3, p. 181-185

Comparison of clinical presentation of respiratory tract infections in H1N1/09-positive and H1N1/09-negative patients

Crisinel, Pierre-Alex ; Barazzone, Constance ; Kaiser, Laurent ; L'Huillier, Arnaud ; Taguebue, Jean ; Wagner, Noémie ; Delcò, Cristina ; Siegrist, Claire-Anne ; Posfay-Barbe, Klara

In: European Journal of Pediatrics, 2012, vol. 171, no. 1, p. 159-166

Trends in Influenza Vaccination Coverage Rates in Germany over Six Seasons from 2001/02 to 2006/07 = Entwicklung der Influenzaimpfraten in Deutschland von 2001/02 bis 2006/07

Blank, Patricia ; Freiburghaus, Andreas ; Ruf, Bernhard ; Schwenkglenks, Matthias ; Szucs, Thomas

In: Medizinische Klinik, 2008, vol. 103, no. 11, p. 761-768

Influenza A(H1N1) infection and severe cardiac dysfunction in adults: A case series = Influenza A(H1N1) Infektion und schwere kardiale Dysfunktion bei Erwachsenen: Eine Fallserie

Wiegand, Jan A. ; Torgersen, Christian ; Bloechlinger, Stefan ; Takala, Jukka ; Dünser, Martin W.

In: Wiener klinische Wochenschrift, 2011, vol. 123, no. 3-4, p. 120-123

Influenza Vaccination Coverage Rates in Germany : A Population-Based Cross-Sectional Analysis of the Seasons 2002/2003 and 2003/2004 = Influenza-Durchimpfungsraten in Deutschland. Eine bevökerungsbezogene Querschnittsuntersuchung der Jahre 2002/2003 und 2003/2004

Müller, Daniela ; Wutzler, Peter ; Szucs, Thomas

In: Medizinische Klinik, 2005, vol. 100, no. 1, p. 6-13