Université de Fribourg

Histone methylation in the nervous system: functions and dysfunctions

Pattaroni, Céline ; Jacob, Claire

In: Molecular Neurobiology, 2012, p. -

Chromatin remodeling is a key epigenetic process controlling the regulation of gene transcription. Local changes of chromatin architecture can be achieved by post-translational modifications of histones such as methylation, acetylation, phosphorylation, ubiquitination, sumoylation, and ADP-ribosylation. These changes are dynamic and allow for rapid repression or de-repression of specific target...