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Histone Methylation in the Nervous System: Functions and Dysfunctions

Pattaroni, Céline ; Jacob, Claire

In: Molecular Neurobiology, 2013, vol. 47, no. 2, p. 740-756

Histone methylation in the nervous system : functions and dysfunctions

Pattaroni, Céline ; Jacob, Claire

In: Molecular Neurobiology, 2013, vol. 47, no. 2, p. 740-756

Chromatin remodeling is a key epigenetic process controlling the regulation of gene transcription. Local changes of chromatin architecture can be achieved by post-translational modifications of histones such as methylation, acetylation, phosphorylation, ubiquitination, sumoylation, and ADP-ribosylation. These changes are dynamic and allow for rapid repression or de-repression of specific target...