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Università della Svizzera italiana

Increasing cancer risk over calendar year in people with multiple sclerosis : a case–control study

Zecca, Chiara ; Disanto, Giulio ; Sacco, Rosaria ; MacLachlan, Sharon ; Kuhle, Jens ; Ramagopalan, Sreeram V. ; Gobbi, Claudio

In: Journal of Neurology, 2021, no. 268, p. 817–824

Background: Data on cancer prevalence and incidence in multiple sclerosis (MS) patients are controversial. This study is aimed at estimating cancer risk in MS patients. Methods: Nested case–control study using data collected between 01/01/1987 and 28/02/2016 from the United Kingdom Clinical Practice Research Datalink. Cancer diagnoses after first MS code (index date) was counted in 10,204 MS...

Università della Svizzera italiana

The MRE11 complex : a versatile toolkit for the repair of broken DNA

Reginato, Giordano ; Cejka, Petr

In: DNA repair, 2020, vol. 91–92, no. July–August, p. 13 p

When DNA breaks, the ends need to be stabilized and processed to facilitate subsequent repair, which can occur by either direct but error-prone end-joining with another broken DNA molecule or a more accurate homology-directed repair by the recombination machinery. At the same time, the presence of broken DNA triggers a signaling cascade that regulates the repair events and cellular progression...