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Université de Neuchâtel

Synthesis, Molecular Structure, and Anticancer Activity of Cationic Arene Ruthenium Metallarectangles

Mattsson, Johan ; Govindaswamy, Padavattan ; Renfrew, Anna K. ; Dyson, Paul J. ; Štěpnička, Petr ; Süss-Fink, Georg ; Therrien, Bruno

In: Organometallics, 2009, vol. 28, no. 15, p. 4350–4357

The cytotoxicities of a new series of cationic metallarectangles have been established in the A2780 ovarian cancer cell line. Interestingly, the large rectangles incorporating 1,2-bis(4-pyridyl)ethylene linkers are ca. 5 times more cytotoxic (IC50 ≤ 6 μM) than the 4,4-bipyridine analogues (IC50 ≥ 30 μM), thus suggesting a correlation between cytotoxicity and the size...

Université de Neuchâtel

Template-Directed Synthesis of Hexanuclear Arene Ruthenium Complexes with Trigonal-Prismatic Architecture Based on 2,4,6-Tris(3-pyridyl)triazine Ligands

Freudenreich, Julien ; Furrer, Julien ; Süss-Fink, Georg ; Therrien, Bruno

In: Organometallics, 2011, vol. 30, no. 5, p. 942–951

Cationic arene ruthenium metalla-prisms of the general formula [Ru6(p-cymene)6(3-tpt)2(OO∩OO)3]6+ (3-tpt = 2,4,6-tris(3-pyridyl)-1,3,5-triazine; OO∩OO = 5,8-dioxido-1,4-naphthoquinonato [1]6+ or 6,11-dioxido-5,12-naphthacenedionato [2]6+) have been obtained from the corresponding...

Université de Neuchâtel

Highly Efficient NMR Enantiodiscrimination of Chiral Octanuclear Metalla-Boxes in Polar Solvent

Barry, Nicolas P.E. ; Austeri, Martina ; Lacour, Jerôme ; Therrien, Bruno

In: Organometallics, 2009, vol. 28, no. 16, p. 4894–4897

Detection of the molecular chirality of a series of octanuclear metalla-boxes can be readily achieved using the NMR chiral solvating agent Λ-BINPHAT in CD3CN: only 0.05 to 0.10 equiv being necessary for a complete baseline separation of some of the proton signals.

Université de Neuchâtel

Organometallic Cages as Vehicles for Intracellular Release of Photosensitizers

Schmitt, Frédéric ; Freudenreich, Julien ; Barry, Nicolas P.E. ; Juillerat-Jeanneret, Lucienne ; Süss-Fink, Georg ; Therrien, Bruno

In: Journal of the American Chemical Society (JACS), 2012, vol. 134, no. 2, p. 754-757

Water-soluble metalla-cages were used to deliver hydrophobic porphin molecules to cancer cells. After internalization, the photosensitizer was photoactivated, significantly increasing the cytotoxicity in cells. During the transport, the photosensitizer remains nonreactive to light, offering a new strategy to tackle overall photosensitization, a limitation often encountered in photodynamic...