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Inhibition of the Kit ligand/c-Kit axis attenuates metastasis in a mouse model mimicking local breast cancer relapse after radiotherapy

Kuonen, François ; Laurent, Jullien ; Secondini, Chiara ; Lorusso, Girieca ; Stehle, Jean-Christophe ; Rausch, Thierry ; Hull, Eveline Faes-van't ; Bieler, Gregory ; Alghisi, Gian Carlo ; Schwendener, Reto A. ; Andrejevic-Blant, Snezana ; Mirimanoff, René-Olivier ; Rüegg, Curzio

In: Clinical Cancer Research, 2012, vol. 18, no. 16, p. 4365-4374

Purpose: Local breast cancer relapse after breast-saving surgery and radiotherapy is associated with increased risk of distant metastasis formation. The mechanisms involved remain largely elusive. We used the well-characterized 4T1 syngeneic, orthotopic breast cancer model to identify novel mechanisms of post-radiation metastasis. Experimental Design: 4T1 cells were injected in 20 Gy...

Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: central pathology review of the EORTC_26981/NCIC_CE.3 trial

Hegi, Monika ; Janzer, Robert-Charles ; Lambiv, Wanyu ; Gorlia, Thierry ; Kouwenhoven, Mathilde ; Hartmann, Christian ; von Deimling, Andreas ; Martinet, Danielle ; Besuchet Schmutz, Nathalie ; Diserens, Annie-Claire ; Hamou, Marie-France ; Bady, Pierre ; Weller, Michael ; van den Bent, Martin ; Mason, Warren ; Mirimanoff, René-Olivier ; Stupp, Roger ; Mokhtari, Karima ; Wesseling, Pieter

In: Acta Neuropathologica, 2012, vol. 123, no. 6, p. 841-852

Radiotherapy suppresses angiogenesis in mice through TGF-ßRI/ALK5-dependent inhibition of endothelial cell sprouting

Imaizumi, Natsuko ; Monnier, Yan ; Hegi, Monika ; Mirimanoff, René-Olivier ; Rüegg, Curzio

In: PLoS ONE, 2010, vol. 5, no. 6, p. e11084

Background: Radiotherapy is widely used to treat cancer. While rapidly dividing cancer cells are naturally considered the main target of radiotherapy, emerging evidence indicates that radiotherapy also affects endothelial cell functions, and possibly also their angiogenic capacity. In spite of its clinical relevance, such putative anti-angiogenic effect of radiotherapy has not been thoroughly...

The Reasons for Discrepancies in TargetVolume Delineation : A SASRO Study on Head-and-Neck and Prostate Cancers = Die Ursachen unterschiedlicher Markierung der Zielvolumina. Eine SASRO-Studie zu Prostata- und HNO-Karzinomen

Jeanneret-Sozzi, Wendy ; Moeckli, Raphaël ; Valley, Jean-François ; Zouhair, Abderrahim ; Ozsahin, Esat ; Mirimanoff, René-Olivier ; of SASRO*, on Behalf SASRO*

In: Strahlentherapie und Onkologie, 2006, vol. 182, no. 8, p. 450-457