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Université de Fribourg

Moraxella species as potential sources of MCR-like polymyxin-resistance determinants

Kieffer, Nicolas ; Nordmann, Patrice ; Poirel, and Laurent

In: Antimicrobial Agents and Chemotherapy, 2017, p. AAC.00129-17

Plasmid-mediated resistance to polymyxins mediated by the MCR-1/-2 determinants has been recently reported in Enterobacteriaceae worldwide. Using PCR-based and cloning strategies, a series of Moraxella species were screened for mcr-like genes. Moraxella spp. that are mainly animal pathogens but may also be human pathogens were identified as potential reservoirs of mcr-like genes.

Université de Fribourg

Screening for fecal carriage of MCR-producing Enterobacteriaceae in healthy humans and primary care patients

Zurfluh, Katrin ; Stephan, Roger ; Widmer, Andreas ; Poirel, Laurent ; Nordmann, Patrice ; Nüesch, Hans-Jakob ; Hächler, Herbert ; Nüesch-Inderbinen, Magdalena

In: Antimicrobial Resistance & Infection Control, 2017, vol. 6, p. 28

The objective of this study was to test the efficacy of an inhibitor of the New Delhi metallo-β- lactamase (NDM-1). Inhibiting expression of this type of antibiotic-resistance gene has the potential to restore antibiotic susceptibility in all bacteria carrying the gene.Methods: We have constructed a peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) that selectively inhibits...

Université de Fribourg

Peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) restores carbapenem susceptibility to NDM-1-positive pathogens in vitro and in vivo

Sully, Erin K. ; Geller, Bruce L. ; Li, Lixin ; Moody, Christina M. ; Bailey, Stacey M. ; Moore, Amy L. ; Wong, Michael ; Nordmann, Patrice ; Daly, Seth M. ; Sturge, Carolyn R. ; Greenberg, David E.

In: Journal of Antimicrobial Chemotherapy, 2017, vol. 72, no. 3, p. 782–790

The objective of this study was to test the efficacy of an inhibitor of the New Delhi metallo-β- lactamase (NDM-1). Inhibiting expression of this type of antibiotic-resistance gene has the potential to restore antibiotic susceptibility in all bacteria carrying the gene.Methods: We have constructed a peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) that selectively inhibits...

Université de Fribourg

Polymyxins: antibacterial activity, susceptibility testing, and resistance mechanisms encoded by plasmids or chromosomes

Poirel, Laurent ; Jayol, Aurélie ; Nordmann, Patrice

In: Clinical Microbiology Reviews, 2017, vol. 30, no. 2, p. 557–596

Polymyxins are well-established antibiotics that have recently regained significant interest as a consequence of the increasing incidence of infections due to multidrug- resistant Gram-negative bacteria. Colistin and polymyxin B are being seriously reconsidered as last-resort antibiotics in many areas where multidrug resistance is observed in clinical medicine. In parallel, the heavy use of...

Université de Fribourg

Cross-resistance to human cationic antimicrobial peptides and to polymyxins mediated by the plasmid-encoded MCR-1?

Dobias, Jan ; Poirel, Laurent ; Nordmann, Patrice

In: Clinical Microbiology and Infection, 2017, p. -

To evaluate whether acquired resistance to cationic antimicrobial peptides (CAMP) group molecules, being normal components of the human immune system, may select co-resistance to antibiotic peptides such as polymyxins, considering they share the same mechanism of action. We aimed to evaluate strains producing the recently identified plasmid-encoded polymyxin resistance determinant MCR-1,...

Université de Fribourg

Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014

Dortet, Laurent ; Cuzon, Gaëlle ; Ponties, V ; Nordmann, Patrice

In: Eurosurveillance, 2017, vol. 22, no. 6, p. -

In 2014, a total of 2,976 Enterobacteriaceae isolates with decreased susceptibility to carbapenems were received at the French Associated National Reference Center for Antibiotic Resistance (NRC) and were characterised for their molecular resistance mechanism to carbapenems and compared with results obtained during 2012 and 2013.The overall number of enterobacterial isolates with decreased...

Université de Fribourg

Rapid Aminoglycoside NP test for rapid detection of multiple aminoglycoside resistance in Enterobacteriaceae

Nordmann, Patrice ; Jayol, Aurélie ; Dobias, Jan ; Poirel, Laurent

In: Journal of Clinical Microbiology, 2017, p. JCM.02107-16

The Rapid Aminoglycoside NP (Nordmann/Poirel) test was developed to rapidly identify multiple aminoglycoside (AG) resistance in Enterobacteriaceae. It is based on the detection of the glucose metabolism related to enterobacterial growth in presence of a defined concentration of amikacin plus gentamicin. Formation of acid metabolites was evidenced by a color change (orange to yellow) of the...