Université de Fribourg

Ag Nanoencapsulation for Antimicrobial Applications

Abram, Sarah-Luise ; Gagnon, Jacinthe ; Priebe, Magdalena ; Hérault, Nelly ; Fromm, Katharina M.

In: CHIMIA International Journal for Chemistry, 2018, vol. 72, no. 4, p. 249–252

Biomaterial-related infections remain a significant challenge in medicine. Antimicrobial materials on the basis of Ag nanoparticles represent a promising solution for this issue. Therefore several Ag-containing nanocontainers and nanorattles have been synthesized and characterized that exhibit remarkable control over the release of Ag+ as antimicrobial active species. Their biological...

Université de Fribourg

Synthesis, characterization, antibacterial activity and cytotoxicity of hollow /TiO₂-coated CeO₂ nanocontainers encapsulating silver nanoparticles for controlled silver release

Gagnon, Jacinthe ; Clift, Martin J. D. ; Vanhecke, Dimitri ; Widnersson, I. E. ; Abram, S.-L. ; Petri-Fink, Alke ; Caruso, R. A. ; Rothen-Rutishauser, Barbara ; Fromm, Katharina M.

In: Journal of Materials Chemistry B, 2016, vol. 4, no. 6, p. 1166–1174

Biomaterials as implants are being applied more extensively in medicine due to their on-going development and associated improvements, and the increase in human life expectancy. Nonetheless, biomaterial-related infections, as well as propagating bacterial resistance, remain significant issues. Therefore, there is a growing interest for silver-based drugs because of their efficient and broad-range...

Université de Fribourg

Toxicity and protective effects of cerium oxide nanoparticles (Nanoceria) depending on their preparation method, particle size, cell type, and exposure route

Gagnon, Jacinthe ; Fromm, Katharina M.

In: European Journal of Inorganic Chemistry, 2015, vol. 2015, no. 27, p. 4510–4517

Nanoceria (cerium oxide nanoparticles) toxicity is currently a concern because of its use in motor vehicles in order to reduce carbon monoxide (CO), nitrogen oxides (NOx), and hydrocarbons in exhaust gases. In addition, many questions arise with respect to its biomedical applications exploiting its potential to protect cells against irradiation and oxidative stress. Indeed, toxicology studies on...

Université de Fribourg

Integrating silver compounds and nanoparticles into ceria nanocontainers for antimicrobial applications

Gagnon, Jacinthe ; Clift, Martin J. D. ; Vanhecke, Dimitri ; Kuhn, Dagmar Alice ; Weber, P. ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Fromm, Katharina M.

In: Journal of Materials Chemistry B, 2015, vol. 3, no. 9, p. 1760–1768

Silver compounds and nanoparticles (NPs) are gaining increasing interest in medical applications, specifically in the treatment and prevention of biomaterial-related infections. However, the silver release from these materials, resulting in a limited antimicrobial activity, is often difficult to control. In this paper, ceria nanocontainers were synthesized by a template-assisted method and were...