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Université de Fribourg

Cardiovascular and orthostatic responses to a festive meal associated with alcohol in young men

Sarafian, Delphine ; Charrière, Nathalie ; Maufrais, Claire ; Montani, Jean-Pierre

In: Frontiers in Physiology, 2019, vol. 10, p. -

Aim: Sharing a festive meal associated with alcohol is quite common. While the cardiovascular changes occurring after meal ingestion of different nutrient composition has been well-established, the effects of ingesting a festive versus a standard meal accompanied with alcohol are less clear. Here, we compared the postprandial hemodynamics, cutaneous and psychomotor performance responses after...

Université de Fribourg

Low 24-hour core body temperature as a thrifty metabolic trait driving catch-up fat during weight regain after caloric restriction

Calonne, Julie ; Arsenijevic, Denis ; Scerri, Isabelle ; Miles-Chan, Jennifer L. ; Montani, Jean-Pierre ; Dulloo, Abdul G.

In: American Journal of Physiology-Endocrinology and Metabolism, 2019, vol. 317, no. 4, p. E699–E709

The recovery of body weight after substantial weight loss or growth retardation is often characterized by a disproportionately higher rate of fat mass vs. lean mass recovery, with this phenomenon of “preferential catch-up fat” being contributed by energy conservation (thrifty) metabolism. To test the hypothesis that a low core body temperature (Tc) constitutes a thrifty metabolic trait...

Université de Fribourg

Assessment of the dose–response relationship between meal protein content and postprandial thermogenesis: effect of sex and the oral contraceptive pill

Duhita, Maharani R. ; Schutz, Yves ; Montani, Jean-Pierre ; Dulloo, Abdul G. ; Miles-Chan, Jennifer L.

In: Nutrients, 2019, vol. 11, no. 7, p. 1599

Implementation of efficacious dietary interventions to regulate energy balance requires understanding of the determinants of individual response. To date, information regarding individual variability in response to elevated meal protein content is lacking. This study investigates whether sex and/or oral contraceptive pill (OCP) use play a role in the response to elevated meal protein in 21...

Université de Fribourg

Reduced skeletal muscle protein turnover and thyroid hormone metabolism in adaptive thermogenesis that facilitates body fat recovery during weight regain

Calonne, Julie ; Isacco, Laurie ; Miles-Chan, Jennifer ; Arsenijevic, Denis ; Montani, Jean-Pierre ; Guillet, Christelle ; Boirie, Yves ; Dulloo, Abdul G.

In: Frontiers in Endocrinology, 2019, vol. 10, p. -

Objective: The recovery of body composition after weight loss is characterized by an accelerated rate of fat recovery (preferential catch-up fat) resulting partly from an adaptive suppression of thermogenesis. Although the skeletal muscle has been implicated as an effector site for such thrifty (energy conservation) metabolism driving catch-up fat, the underlying mechanisms remain to be...

Université de Fribourg

Early and late cardiovascular and metabolic responses to mixed wine: effect of drink temperature

Sarafian, Delphine ; Maufrais, Claire ; Montani, Jean-Pierre

In: Frontiers in Physiology, 2018, vol. 9, p. -

Aim: Red wine is usually ingested as an unmixed drink. However, mixtures of wine with juices and/or sucrose (mixed wine) are becoming more and more popular and could be ingested at either cold or hot temperature. Although the temperature effects on the cardiovascular system have been described for water and tea, with greater energy expenditure (EE) and lower cardiac workload with a colder...

Université de Fribourg

The contribution of Swiss scientists to the assessment of energy metabolism

Montani, Jean-Pierre ; Schutz, Yves ; Dulloo, Abdul G.

In: European Journal of Clinical Nutrition, 2018, vol. 72, no. 5, p. 665–679

Although Switzerland is considered a small country, it has its share in discoveries, inventions and developments for the assessment of energy metabolism. This includes seminal contributions to respiratory and metabolic physiology and to devices for measuring energy expenditure by direct and indirect calorimetry in vivo in humans and small animals (as well as in vitro in organs/tissues), for...

Université de Fribourg

Cardiovascular and metabolic responses to the ingestion of caffeinated herbal tea: drink it hot or cold?

Maufrais, Claire ; Sarafian, Delphine ; Dulloo, Abdul ; Montani, Jean-Pierre

In: Frontiers in Physiology, 2018, vol. 9, p. -

Tea is usually consumed at two temperatures (as hot tea or as iced tea). However, the importance of drink temperature on the cardiovascular system and on metabolism has not been thoroughly investigated. The purpose of this study was to compare the cardiovascular, metabolic and cutaneous responses to the ingestion of caffeinated herbal tea (Yerba Mate) at cold or hot temperature in healthy...

Université de Fribourg

Arginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis

Yu, Yi ; Xiong, Yuyan ; Montani, Jean-Pierre ; Yang, Zhihong ; Ming, Xiu-Fen

In: Cell Death & Disease, 2018, vol. 9, no. 3, p. 313

Type-II L-arginine:ureahydrolase, arginase-II (Arg-II), is shown to activate mechanistic target of rapamycin complex 1 (mTORC1) pathway and contributes to cell senescence and apoptosis. In an attempt to elucidate the underlying mechanism, we identified myosin-1b (Myo1b) as a mediator. Overexpression of Arg-II induces re-distribution of lysosome and mTOR but not of tuberous sclerosis complex...

Université de Fribourg

Orthostatic intolerance in older persons: etiology and countermeasures

Goswami, Nandu ; Blaber, Andrew P. ; Hinghofer-Szalkay, Helmut ; Montani, Jean-Pierre

In: Frontiers in Physiology, 2017, vol. 8, p. -

Orthostatic challenge produced by upright posture may lead to syncope if the cardiovascular system is unable to maintain adequate brain perfusion. This review outlines orthostatic intolerance related to the aging process, long-term bedrest immobilization, drugs, and disease. Aging-associated illness or injury due to falls often leads to hospitalization. Given that older patients spend up to...