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Université de Fribourg

Somatic calcium level reports integrated spiking activity of cerebellar interneurons in vitro and in vivo

Franconville, Romain ; Revet, Gaëlle ; Astorga, Guadalupe ; Schwaller, Beat ; Llano, Isabel

In: Journal of Neurophysiology, 2011, vol. 106, no. 4, p. 1793-1805

We examined the relationship between somatic Ca²⁺ signals and spiking activity of cerebellar molecular layer interneurons (MLIs) in adult mice. Using two-photon microscopy in conjunction with cell-attached recordings in slices, we show that in tonically firing MLIs loaded with high-affinity Ca²⁺ probes, Ca²⁺-dependent fluorescence transients are absent. Spike-triggered averages of...