Refine my results

Mutation of the circadian clock gene Per2 alters vascular endothelial function

Viswambharan, Hema ; Carvas, João Miguel ; Antic, Vladan ; Marecic, Ana ; Jud, Corinne ; Zaugg, Christian E. ; Ming, Xiu-Fen ; Montani, Jean-Pierre ; Albrecht, Urs ; Yang, Zhihong

In: Circulation, 2007, vol. 115, p. 2188-2195

Background— The circadian clock regulates biological processes including cardiovascular function and metabolism. In the present study, we investigated the role of the circadian clock gene Period2 (Per2) in endothelial function in a mouse model. Methods and Results— Compared with the wild-type littermates, mice with Per2 mutation exhibited impaired...

Role of mutation of the circadian clock gene Per2 in cardiovascular circadian rhythms

Vukolic, Ana ; Antic, Vladan ; Vliet, Bruce N. Van ; Yang, Zhihong ; Albrecht, Urs ; Montani, Jean-Pierre

In: American Journal of Physiology Regulatory, Integrative and Comparative Physiolology, 2010, p. -

Alterations in the circadian blood pressure pattern are frequently observed in hypertension and lead to increased cardiovascular morbidity. However, there are no studies that have investigated a possible implication of the Period2 gene, a key component of the molecular circadian clock, on the circadian rhythms of blood pressure and heart rate. To address this question, we monitored blood...

Differential Sorting of the Vesicular Glutamate Transporter 1 into a Defined Vesicular Pool Is Regulated by Light Signaling Involving the Clock Gene Period2

Yelamanchili, Sowmya V. ; Pendyala, Gurudutt ; Brunk, Irene ; Darna, Mahesh ; Albrecht, Urs ; Ahnert-Hilger, Gudrun

In: The Journal of Biological Chemistry, 2006, vol. 281, no. 23, p. 15671–15679

Synaptic strength depends on the amount of neurotransmitter stored in synaptic vesicles. The vesicular transmitter content has recently been shown to be directly dependent on the expression levels of vesicular neurotransmitter transporters indicating that the transport capacity of synaptic vesicles is a critical determinant for synaptic efficacy. Using synaptic vesicles prepared from whole brain...

Ethanol self-administration and reinstatement of ethanol-seeking behavior in Per1Brdm1 mutant mice

Zghoul, Tarek ; Abarca, Carolina ; Sanchis-Segura, Carles ; Albrecht, Urs ; Schumann, Gunter ; Spanagel, Rainer

In: Psychopharmacology, 2007, vol. 190, no. 1, p. 13-19

Rationale Alcohol consumption shows circadian rhythmicity, i.e., alcohol preference and intake change with circadian time. Circadian rhythmicity is controlled by a biological clock, which has been shown to govern behavioral, physiological, and hormonal processes in synchronization with internal as well as external cues. Molecular components of the clock include circadian clock genes such as...

Fragile X-related proteins regulate mammalian circadian behavioral rhythms

Zhang, Jing ; Fang, Zhe ; Jud, Corinne ; Vansteensel, Mariska J. ; Kaasik, Krista ; Lee, Cheng Chi ; Albrecht, Urs ; Tamanini, Filippo ; Meijer, Johanna H. ; Oostra, Ben A. ; Nelson, David L.

In: The American Journal of Human Genetics, 2008, vol. 83, no. 1, p. 43-52

mPer1 and mPer2 mutant mice show regular spatial and contextual learning in standardized tests for hippocampus-dependent learning

Zueger, M. ; Urani, A. ; Chourbaji, S. ; Zacher, C. ; Lipp, H. P. ; Albrecht, Urs ; Spanagel, R. ; Wolfer, D. P. ; Gass, P.

In: Journal of Neural Transmission, 2006, vol. 113, no. 3, p. 347-356

Learning and memory, like most physiological processes, seem to be under the control of circadian rhythm. The recently cloned mPer1 and mPer2 genes play an important role in the regulation of the circadian rhythm. In this study, we tested mPer1 and mPer2 mutant mice in two different learning and memory paradigms, a water-maze place navigation task and contextual...