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Université de Fribourg

Adaptive thermogenesis in human body weight regulation: more of a concept than a measurable entity?

Dulloo, Abdul G. ; Jacquet, Jean ; Montani, Jean-Pierre ; Schutz, Yves

In: Obesity Reviews, 2012, vol. 13, no. S2, p. 105–121

According to Lavoisier, ‘Life is combustion’. But to what extent humans adapt to changes in food intake through adaptive thermogenesis – by turning down the rate of heat production during energy deficit (so as to conserve energy) or turning it up during overnutrition (so as to dissipate excess calories) – has been one of the most controversial issues in nutritional sciences over the past...

Université de Fribourg

Body composition, inflammation and thermogenesis in pathways to obesity and the metabolic syndrome: an overview

Dulloo, Abdul G. ; Montani, Jean-Pierre

In: Obesity Reviews, 2012, vol. 13, no. S2, p. 1–5

According to the World Health Organization, overweight and obesity are defined as abnormal or excessive fat accumulation that presents a risk to health. What constitutes ‘abnormal’ fat accumulation in this definition is not specified, but this most likely represents a consensus term that encapsulates the importance of adipose tissue dysfunctions, rather than solely excess fat per se, in the...

Université de Fribourg

Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity

Speakman, John R. ; Levitsky, David A. ; Allison, David B. ; Bray, Molly S. ; Castro, John M. de ; Clegg, Deborah J. ; Clapham, John C. ; Dulloo, Abdul G. ; Gruer, Laurence ; Haw, Sally ; Hebebrand, Johannes ; Hetherington, Marion M. ; Higgs, Susanne ; Jebb, Susan A. ; Loos, Ruth J. F. ; Luckman, Simon ; Luke, Amy ; Mohammed-Ali, Vidya ; O’Rahilly, Stephen ; Pereira, Mark ; Perusse, Louis ; Robinson, Tom N. ; Rolls, Barbara ; Symonds, Michael E. ; Westerterp-Plantenga, Margriet S.

In: Disease Models & Mechanisms, 2011, vol. 4, p. 733-745

The close correspondence between energy intake and expenditure over prolonged time periods, coupled with an apparent protection of the level of body adiposity in the face of perturbations of energy balance, has led to the idea that body fatness is regulated via mechanisms that control intake and energy expenditure. Two models have dominated the discussion of how this regulation might take place....

Université de Fribourg

PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance

Becattini, Barbara ; Marone, Romina ; Zani, Fabio ; Arsenijevic, Denis ; Seydoux, Josiane ; Montani, Jean-Pierre ; Dulloo, Abdul G. ; Thorens, Bernard ; Preitner, Frédéric ; Wymann, Matthias P. ; Solinas, Giovanni

In: Proceedings of the National Academy of Sciences of the United States of America, 2011, vol. 108, no. 42, p. E854-E863

Obesity is associated with a chronic low-grade inflammation, and specific antiinflammatory interventions may be beneficial for the treatment of type 2 diabetes and other obesity-related diseases. The lipid kinase PI3Kγ is a central proinflammatory signal transducer that plays a major role in leukocyte chemotaxis, mast cell degranulation, and endothelial cell activation. It was also reported that...

Université de Fribourg

Hepatic mitochondrial energetics during catch-Up fat with high-Fat diets rich in lard or safflower oil

Crescenzo, Raffaella ; Bianco, Francesca ; Falcone, Italia ; Tsalouhidou, Sofia ; Yepuri, Gayathri ; Mougios, Vassilis ; Dulloo, Abdul G. ; Liverini, Giovanna ; Iossa, Susanna

In: Obesity, 2011, p. -

We have investigated whether altered hepatic mitochondrial energetics could explain the differential effects of high-fat diets with low or high ω6 polyunsaturated fatty acid content (lard vs. safflower oil) on the efficiency of body fat recovery (catch-up fat) during refeeding after caloric restriction. After 2 weeks of caloric restriction, rats were isocalorically refed with a low-fat diet (LF)...

Université de Fribourg

The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis

Hursel, R. ; Viechtbauer, W. ; Dulloo, Abdul G. ; Tremblay, A. ; Tappy, L. ; Rumpler, W. ; Westerterp-Plantenga, M. S.

In: Obesity Reviews, 2011, vol. 12, no. 7, p. e573–e581

Different outcomes of the effect of catechin-caffeine mixtures and caffeine-only supplementation on energy expenditure and fat oxidation have been reported in short-term studies. Therefore, a meta-analysis was conducted to elucidate whether catechin-caffeine mixtures and caffeine-only supplementation indeed increase thermogenesis and fat oxidation. First, English-language studies measuring daily...

Université de Fribourg

Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA

Yepuri, Gayathri ; Marcelino, Helena ; Shahkhalili, Yasaman ; Aprikian, Olivier ; Macé, Katherine ; Seydoux, Josiane ; Miles, Jennifer L. ; Montani, Jean-Pierre ; Dulloo, Abdul G.

In: British Journal of Nutrition, 2011, vol. 105, p. 1750-1763

The present study investigates whether excessive fat accumulation and hyperinsulinaemia during catch-up growth on high-fat diets are altered by n-6 and n-3 PUFA derived from oils rich in either linoleic acid (LA), α-linolenic acid (ALA), arachidonic acid (AA) or DHA. It has been shown that, compared with food-restricted rats refed a high-fat (lard) diet low in PUFA, those refed...

Université de Fribourg

Body composition phenotypes in pathways to obesity and the metabolic syndrome

Dulloo, Abdul G. ; Jacquet, Jean ; Solinas, Giovanni ; Montani, Jean-Pierre ; Schutz, Y.

In: International Journal of Obesity, 2010, vol. 34, p. S4–S17

Dynamic changes in body weight have long been recognized as important indicators of risk for debilitating diseases. While weight loss or impaired growth can lead to muscle wastage, as well as to susceptibility to infections and organ dysfunctions, the development of excess fat predisposes to type 2 diabetes and cardiovascular diseases, with insulin resistance as a central feature of the disease...

Université de Fribourg

A role for pancreatic beta-cell secretory hyperresponsiveness in catch-up growth hyperinsulinemia: Relevance to thrifty catch-up fat phenotype and risks for type 2 diabetes

Casimir, Marina ; Andrade, Paula B. de ; Gjinovci, Asllan ; Montani, Jean-Pierre ; Maechler, Pierre ; Dulloo, Abdul G.

In: Nutrition & Metabolism, 2011, vol. 8, no. 2, p. 2

Current notions about mechanisms by which catch-up growth predisposes to later type 2 diabetes center upon those that link hyperinsulinemia with an accelerated rate of fat deposition (catch-up fat). Using a rat model of semistarvation-refeeding in which catch-up fat is driven solely by elevated metabolic efficiency associated with hyperinsulinemia, we previously reported that insulin-stimulated...