In: Brain, 2016, vol. 139, no. 9, p. 2503-2515
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In: American Journal of Physiology - Renal Physiology, 2011, vol. 299, no. 6, p. F1473-F1485
Aldosterone and corticosterone bind to mineralocorticoid (MR) and glucocorticoid receptors (GR), which, upon ligand binding, are thought to translocate to the cell nucleus to act as transcription factors. Mineralocorticoid selectivity is achieved by the 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) that inactivates 11β-hydroxy glucocorticoids. High expression levels of 11β-HSD2...
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In: Current Neurology and Neuroscience Reports, 2014, vol. 14, no. 2, p. 1-10
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In: Nature Nanotechnology, 2010, vol. 5, p. 423 - 428
The aggregation of proteins is central to many aspects of daily life, including food processing, blood coagulation, eye cataract formation disease and prion-related neurodegenerative infections. However, the physical mechanisms responsible for amyloidosis—the irreversible fibril formation of various proteins that is linked to disorders such as Alzheimer's, Creutzfeldt–Jakob and Huntington's...
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In: Publius: The Journal of Federalism, 2003, vol. 33, no. 1, p. 1-21
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In: Annali di Matematica Pura ed Applicata (1923 -), 2020, vol. 199, no. 1, p. 147–186
We prove a Koebe distortion theorem for the average derivative of a quasiconformal mapping between domains in the sub-Riemannian Heisenberg group H1. Several auxiliary properties of quasiconformal mappings between subdomains of H1 are proven, including BMO estimates for the logarithm of the Jacobian. Applications of the Koebe theorem include diameter bounds for images of curves, comparison of...
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In: Water Resources Research, 2014, p. -
Projections of discharge are key for future water resources management. These projections are subject to uncertainties, which are difficult to handle in the decision process on adaptation strategies. Uncertainties arise from different sources such as the emission scenarios, the climate models and their post-processing, the hydrological models and natural variability. Here we present a detailed...
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In: Mathematische Annalen, 2019, vol. 373, no. 1, p. 237–251
The goal of this note is to affirm a local version of conjecture of Nisse–Sottile [19] on higher convexity of complements of tropical varieties, while providing a family of counter-examples for the global Nisse–Sottle conjecture in any codimension and dimension higher than one. Moreover, it is shown that, surprisingly, this family also provides a family of counter-examples for the...
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In: Neuroscience, 2009, vol. 159, no. 1, p. 47-58
Multiple theories have been proposed for sensation seeking and vulnerability to impulse-control disorders [Zuckerman M, Kuhlman DM (2000) Personality and risk-taking: Common biosocial factors. J Pers 68:999–1029], and many of these rely on a dopamine system deficit. Available animal models reproduce only some behavioral symptoms and seem devoid of construct validity. We used lentivirus tools...
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In: The International Journal of Neuropsychopharmacology, 2010, p. -
Dysfunction of brain dopamine transporter (DAT) has been associated with sensation seeking and impulse-control disorders. We recently generated a new animal model by stereotaxical inoculation of lentiviral vectors, which allowed localized intra-accumbal delivery of modulators for DAT gene: GFP (green fluorescent protein) control, silencers (Sil), a regulatable enhancer (DAT+), or both (DAT+Sil)....
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