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Université de Fribourg

Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA

Yepuri, Gayathri ; Marcelino, Helena ; Shahkhalili, Yasaman ; Aprikian, Olivier ; Macé, Katherine ; Seydoux, Josiane ; Miles, Jennifer L. ; Montani, Jean-Pierre ; Dulloo, Abdul G.

In: British Journal of Nutrition, 2011, vol. 105, p. 1750-1763

The present study investigates whether excessive fat accumulation and hyperinsulinaemia during catch-up growth on high-fat diets are altered by n-6 and n-3 PUFA derived from oils rich in either linoleic acid (LA), α-linolenic acid (ALA), arachidonic acid (AA) or DHA. It has been shown that, compared with food-restricted rats refed a high-fat (lard) diet low in PUFA, those refed...

Université de Fribourg

Thrifty energy metabolism in catch-up growth trajectories to insulin and leptin resistance

Dulloo, Abdul G.

In: Best Practice & Research Clinical Endocrinology & Metabolism, 2008, vol. 22, no. 1, p. 155-171

Catch-up growth early in life (after fetal, neonatal or infantile growth retardation) is a major risk factor for later obesity, type-2 diabetes and cardiovascular diseases. These risks are generally interpreted alongside teleological arguments that environmental exposures which hinder growth early in life lead to programming of ‘thrifty mechanisms’ that are adaptive during the period of...