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Université de Fribourg

Standing economy: does the heterogeneity in the energy cost of posture maintenance reside in differential patterns of spontaneous weight-shifting?

Miles-Chan, Jennifer L. ; Fares, Elie-Jacques ; Berkachy, Redina ; Jacquet, Philippe ; Isacco, Laurie ; Schutz, Yves ; Montani, Jean-Pierre ; Dulloo, Abdul G.

In: European Journal of Applied Physiology, 2017, vol. 117, no. 4, p. 795–807

Due to sedentarity-associated disease risks, there is much interest in methods to increase low-intensity physical activity. In this context, it is widely assumed that altering posture allocation can modify energy expenditure (EE) to impact body-weight regulation and health. However, we have recently shown the existence of two distinct phenotypes pertaining to the energy cost of...

Université de Fribourg

Reliability of low‐power cycling efficiency in energy expenditure phenotyping of inactive men and women

Fares, Elie-Jacques ; Isacco, Laurie ; Monnard, Cathriona R. ; Miles-Chan, Jennifer L. ; Montani, Jean-Pierre ; Schutz, Yves ; Dulloo, Abdul G.

In: Physiological Reports, 2017, vol. 5, no. 9, p. e13233

Standardized approaches to assess human energy expenditure (EE) are well defined at rest and at moderate to high‐intensity exercise, but not at light intensity physical activities energetically comparable with those of daily life (i.e., 1.5–4 times the resting EE, i.e., 1.5–4 METs). Our aim was to validate a graded exercise test for assessing the energy cost of low‐intensity dynamic...

Université de Fribourg

Nutrition, movement and sleep behaviours: their interactions in pathways to obesity and cardiometabolic diseases

Dulloo, Abdul G. ; Miles-Chan, Jennifer L. ; Montani, Jean-Pierre

In: Obesity Reviews, 2017, vol. 18, no. S1, p. 3–6

Among the multitude of dietary and lifestyle behaviours that have been proposed to contribute to the obesity epidemic, those that have generated considerable research scrutiny in the past decade are centred upon sleep behaviours, sedentary behaviours (sitting or lying while awake) and diminished low-level physical activities of everyday life, with each category of behaviours apparently...

Université de Fribourg

Passive and active roles of fat-free mass in the control of energy intake and body composition regulation

Dulloo, Abdul G. ; Jacquet, Jean ; Miles-Chan, Jennifer L ; Schutz, Yves

In: European Journal of Clinical Nutrition, 2017, vol. 71, no. 3, p. 353–357

While putative feedback signals arising from adipose tissue are commonly assumed to provide the molecular links between the body’s long-term energy requirements and energy intake, the available evidence suggests that the lean body or fat-free mass (FFM) also plays a role in the drive to eat. A distinction must, however, be made between a ‘passive’ role of FFM in driving energy intake,...

Université de Fribourg

Polyunsaturated fatty acids stimulate de novo lipogenesis and improve glucose homeostasis during refeeding with high fat diet

Crescenzo, Raffaella ; Mazzoli, Arianna ; Cancelliere, Rosa ; Bianco, Francesca ; Giacco, Antonia ; Liverini, Giovanna ; Dulloo, Abdul G. ; Iossa, Susanna

In: Frontiers in Physiology, 2017, vol. 8, p. -

The recovery of body weight after a period of caloric restriction is accompanied by an enhanced efficiency of fat deposition and hyperinsulinemia—which are exacerbated by isocaloric refeeding on a high fat diet rich in saturated and monounsaturated fatty acids (SFA-MUFA), and poor in polyunsaturated fatty acids (PUFA), and associated with a blunting of de novo lipogenesis in adipose tissue...

Université de Fribourg

Collateral fattening: when a deficit in lean body mass drives overeating

Dulloo, Abdul G.

In: Obesity, 2017, vol. 25, no. 2, p. 277–279

In his last review entitled “Some Adventures in Body Composition,” Gilbert Forbes reminded us that “lean body mass and body fat are in a sense companions.” To what extent the lean body mass (or fat-free mass) component in this companionship impacts on energy intake is rarely a topic for discussion, amid a dominant adipocentric view of appetite control. Yet an analysis of the few human...

Université de Fribourg

Isometric thermogenesis at rest and during movement: a neglected variable in energy expenditure and obesity predisposition

Dulloo, Abdul G. ; Miles-Chan, Jennifer L. ; Montani, Jean-Pierre ; Schutz, Yves

In: Obesity Reviews, 2017, vol. 18, no. S1, p. 56–64

Isometric thermogenesis as applied to human energy expenditure refers to heat production resulting from increased muscle tension. While most physical activities consist of both dynamic and static (isometric) muscle actions, the isometric component is very often essential for the optimal performance of dynamic work given its role in coordinating posture during standing, walking and most...