Université de Fribourg

NKCC1 downregulation induces hyperpolarizing shift of GABA responsiveness at near term fetal stages in rat cultured dorsal root ganglion neurons

Chabwine, Joelle N ; Talavera, Karel ; Bosch, Ludo Van Den ; Callewaert, Geert

In: BMC Neuroscience, 2015, vol. 16, no. 1, p. 41

GABA A receptor-mediated neurotransmission is greatly influenced by cation-chloride cotransporter activity during developmental stages. In embryonic neurons Na–K–2Cl (NKCC1) cotransporters mediate active chloride uptake, thus increasing the intracellular chloride concentration associated with GABA-induced depolarization. At fetal stages near term, oxytocin-induced NKCC1 downregulation has...

Université de Fribourg

Upregulated expression of oncomodulin, the beta isoform of parvalbumin, in perikarya and axons in the diencephalon of parvalbumin knockout mice

Csillik, B. ; Schwaller, Beat ; Mihaly, A. ; Henzi, Thomas ; Losonczi, E. ; Knyihar-Csillik, E.

In: Neuroscience, 2010, vol. 165, no. 3, p. 749-757

The calcium-binding proteins parvalbumin, calbindin D-28k, calretinin and calcineurin are present in subsets of GABAergic gigantic calyciform presynaptic terminals of the reticular thalamic nucleus (RTN). Previously it was hypothesized that GABA and calcium-binding proteins including parvalbumin are not only colocalized in the same neuron subpopulation, but that GABA synthesis and parvalbumin...