Université de Fribourg

The calcium-binding protein parvalbumin modulates the firing 1 properties of the reticular thalamic nucleus bursting neurons

Albéri, Lavinia ; Lintas, Alessandra ; Kretz, Robert ; Schwaller, Beat ; Villa, Alessandro E. P.

In: Journal of Neurophysiology, 2013, vol. 109, no. 11, p. 2827–2841

The reticular thalamic nucleus (RTN) of the mouse is characterized by an overwhelming majority of GABAergic neurons receiving afferences from both the thalamus and the cerebral cortex and sending projections mainly on thalamocortical neurons. The RTN neurons express high levels of the “slow Ca²⁺ buffer” parvalbumin (PV) and are characterized by low-threshold Ca²⁺ currents,...

Université de Fribourg

Somatic calcium level reports integrated spiking activity of cerebellar interneurons in vitro and in vivo

Franconville, Romain ; Revet, Gaëlle ; Astorga, Guadalupe ; Schwaller, Beat ; Llano, Isabel

In: Journal of Neurophysiology, 2011, vol. 106, no. 4, p. 1793-1805

We examined the relationship between somatic Ca²⁺ signals and spiking activity of cerebellar molecular layer interneurons (MLIs) in adult mice. Using two-photon microscopy in conjunction with cell-attached recordings in slices, we show that in tonically firing MLIs loaded with high-affinity Ca²⁺ probes, Ca²⁺-dependent fluorescence transients are absent. Spike-triggered averages of...

Université de Fribourg

The absence of the calcium-buffering protein calbindin is associated with faster age-related decline in hippocampal metabolism

Moreno, Herman ; Burghardt, Nesha S. ; Vela-Duarte, Daniel ; Masciotti, James ; Hua, Fan ; Fenton, André A. ; Schwaller, Beat ; Small, Scott A.

In: Hippocampus, 2012, vol. 22, p. 1107-1120

Although reductions in the expression of the calcium-buffering proteins calbindin D-28K (CB) and parvalbumin (PV) have been observed in the aging brain, it is unknown whether these changes contribute to age-related hippocampal dysfunction. To address this issue, we measured basal hippocampal metabolism and hippocampal structure across the lifespan of C57BL/6J, calbindin D-28k knockout (CBKO) and...

Université de Fribourg

Upregulated expression of oncomodulin, the beta isoform of parvalbumin, in perikarya and axons in the diencephalon of parvalbumin knockout mice

Csillik, B. ; Schwaller, Beat ; Mihaly, A. ; Henzi, Thomas ; Losonczi, E. ; Knyihar-Csillik, E.

In: Neuroscience, 2010, vol. 165, no. 3, p. 749-757

The calcium-binding proteins parvalbumin, calbindin D-28k, calretinin and calcineurin are present in subsets of GABAergic gigantic calyciform presynaptic terminals of the reticular thalamic nucleus (RTN). Previously it was hypothesized that GABA and calcium-binding proteins including parvalbumin are not only colocalized in the same neuron subpopulation, but that GABA synthesis and parvalbumin...

Université de Fribourg

The continuing disappearance of “pure” Ca²⁺ buffers

Schwaller, Beat

In: Cellular and Molecular Life Sciences, 2009///doi:10.1007/s00018-008-8564-6

Advances in the understanding of a class of Ca²⁺-binding proteins usually referred to as “Ca²⁺ buffers” are reported. Proteins historically embraced within this group include parvalbumins (α and β), calbindin-D9k, calbindin-D28k and calretinin. Within the last few years a wealth of data has accumulated that allow a better understanding of the functions of particular family members of...

Université de Fribourg

The role of parvalbumin and calbindin D28k in experimental scrapie

Voigtländer, T. ; Unterberger, U. ; Guentchev, M. ; Schwaller, Beat ; Celio, Marco R. ; Meyer, M. ; Budka, H.

In: Neuropathology and Applied Neurobiology, 2008, vol. 34, no. 4, p. 435 - 445

Aims: Prion diseases are generally characterized by pronounced neuronal loss. In particular, a subpopulation of inhibitory neurones, characterized by the expression of the calcium-binding protein parvalbumin (PV), is selectively destroyed early in the course of human and experimental prion diseases. By contrast, nerve cells expressing calbindin D28k (CB), another calcium-binding protein, as well...