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Acute endotoxemia in mice induces downregulation of megalin and cubilin in the kidney

Schreiber, Andrea ; Theilig, Franziska ; Schweda, Frank ; Höcherl, Klaus

In: Kidney International, 2012, p. -

Severe sepsis is often accompanied by acute renal failure with renal tubular dysfunction. Albuminuria is a common finding in septic patients and we studied whether it was due to an impairment of proximal tubular endocytosis of filtered albumin. We studied the regulation of megalin and cubilin, the two critical multiligand receptors responsible for albumin absorption, during severe experimental...

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Developmental regulation of gene expression and astrocytic processes may explain selective hippocampal vulnerability

Lavenex, Pierre ; Sugden, Steven G. ; Davis, Ryan R. ; Gregg, Jeffrey P. ; Lavenex, Pamela Banta

In: Hippocampus, 2010, p. -

The hippocampus plays a central role in the brain network that is essential for memory function. Paradoxically, the hippocampus is also the brain structure that is most sensitive to hypoxic-ischemic episodes. Here, we show that the expression of genes associated with glycolysis and glutamate metabolism in astrocytes and the coverage of excitatory synapses by astrocytic processes undergo...

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