Université de Fribourg

Parvalbumin-expressing ependymal cells in rostral lateral ventricle wall adhesions contribute to aging-related ventricle stenosis in mice

Filice, Federica ; Celio, Marco R. ; Babalian, Alexandre ; Blum, Walter ; Szabolcsi, Viktoria

In: Journal of Comparative Neurology, 2017, vol. 525, no. 15, p. 3266–3285

Aging-associated ependymal-cell pathologies can manifest as ventricular gliosis, ventricle enlargement, or ventricle stenosis. Ventricle stenosis and fusion of the lateral ventricle (LV) walls is associated with a massive decline of the proliferative capacities of the stem cell niche in the affected subventricular zone (SVZ) in aging mice. We examined the brains of adult C57BL/6 mice and...

Université de Fribourg

De novo expression of parvalbumin in ependymal cells in response to brain injury promotes ependymal remodeling and wound repair

Szabolcsi, Viktória ; Celio, Marco R.

In: Glia, 2014, p. -

The calcium-binding protein parvalbumin (PV) hallmarks subpopulations of interneurons in the murine brain. We serendipitously observed the de novo expression of PV in ependymal cells of the lateral ventricle wall following in vivo lesioning and brain slicing for the preparation of organotypic hippocampal slice cultures (OHSCs). In OHSCs, de novo PV-expression begins shortly after the onset of...