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Université de Fribourg

Emerging paradigms and questions on pro-angiogenic bone marrow-derived myelomonocytic cells

Laurent, Julien ; Touvrey, Cédric ; Botta, Francesca ; Kuonen, François ; Rüegg, Curzio

In: The International Journal of Developmental Biology, 2011, vol. 55, p. 527-534

Cancer-related inflammation has emerged in recent years as a major event contributing to tumor angiogenesis, tumor progression and metastasis formation. Bone marrow-derived and inflammatory cells promote tumor angiogenesis by providing endothelial progenitor cells that differentiate into mature endothelial cells, and by secreting pro-angiogenic factors and remodeling the extracellular matrix...

Université de Fribourg

Autologous stem cell transplantation: leukapheresis product has anti-angiogenic effects in vivo correlating with neutrophil-derived VEGFR1

Luethy, Anita ; Stenner, Frank ; Lohri, Corinne ; Muller, Christoph ; Samaras, Panagiotis ; Steiner, Rudolf ; Broek, Maries Van Den ; Mischo, Axel ; Renner, Christoph ; Knuth, Alexander ; Rüegg, Curzio ; Wenger, Roland H. ; Zweifel, Martin

In: Anticancer Research, 2011, vol. 31, no. 10, p. 3115-3124

Background: High-dose chemotherapy (HDC) followed by autologous stem cell transplantation (ASCT) is used for the treatment of hemato-oncologic malignancies. In this study, we measured the effect of HDC/ASCT on plasma concentrations of antiangiogenic soluble vascular endothelial growth factor receptor 1 (sVEGFR1) and of leukapheresis products (LP) and patient serum on chick chorioallantoic...

Université de Fribourg

Decrease in VEGF expression induces intussusceptive vascular pruning

Hlushchuk, Ruslan ; Ehrbar, Martin ; Reichmuth, Philipp ; Heinimann, Niklas ; Styp-Rekowska, Beata ; Escher, Robert ; Baum, Oliver ; Lienemann, Philipp ; Makanya, Andrew N. ; Keshet, Eli ; Djonov, Valentin

In: Arteriosclerosis, Thrombosis, and Vascular Biology, 2011, vol. 31, p. 2836-2844

Objective—The concept of vascular pruning, the “cuting-off” of vessels, is gaining importance due to expansion of angio-modulating therapies. The proangiogenic effects of vascular endothelial growth factor (VEGF) are broadly described, but the mechanisms of structural alterations by its downregulation are not known.Methods and Results—VEGF165-releasing hydrogels were applied onto the...

Université de Fribourg

Angiofil®-mediated visualization of the vascular system by microcomputed tomography: a feasibility study

Grabherr, Silke ; Hess, Andreas ; Karolczak, Marek ; Thali, Michael J. ; Friess, Sebastian D. ; Kalender, Willi A. ; Dirnhofer, Richard ; Djonov, Valentin

In: Microscopy Research and Technique, 2008, vol. 71, no. 7, p. 551 - 556

Visualization of the vascular systems of organs or of small animals is important for an assessment of basic physiological conditions, especially in studies that involve genetically manipulated mice. For a detailed morphological analysis of the vascular tree, it is necessary to demonstrate the system in its entirety. In this study, we present a new lipophilic contrast agent, Angiofil®, for...