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Université de Fribourg

O-linked β-N-acetylglucosamine during hyperglycemia exerts both anti-inflammatory and pro-oxidative properties in the endothelial system

Rajapakse, Angana Gupta ; Ming, Xiu-Fen ; Carvas, João Miguel ; Yang, Zhihong

In: Oxidative Medicine & Cellular Longevity, 2009, vol. 2, no. 3, p. 172 - 175

Elevated cellular levels of protein O-linked β-N-acetylglucosamine (O-GlcNAc) through hexosamine biosynthesis pathway (HBP) are suggested to contribute to cardiovascular adverse effects under chronic hyperglycemic condition associated with oxidative stress and inflammation. Conversely, enhancing O-GlcNAc levels have also been demonstrated being protective against myocardial ischemia/reperfusion...

Université de Fribourg

The hexosamine biosynthesis inhibitor azaserine prevents endothelial inflammation and dysfunction under hyperglycemic condition through antioxidant effects

Rajapakse, Angana Gupta ; Ming, Xiu-Fen ; Carvas, João Miguel ; Yang, Zhihong

In: American Journal of Physiology - Heart and Circulatory Physiology, 2009, vol. 296, p. H815-H822

Hexosamine biosynthetic pathway (HBP) accounts for some cardiovascular adverse effects of hyperglycemia. We investigated whether the HBP inhibitor azaserine protects against hyperglycemia-induced endothelial damage dependently of HBP. Human endothelial cells isolated from umbilical veins were exposed either to a high (30.5 mmol/l) or low concentration of glucose (5.5 mmol/l) for 4 days, followed...