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Anti-Nogo-A antibody treatment enhances sprouting of corticospinal axons rostral to a unilateral cervical spinal cord lesion in adult macaque monkey

Freund, Patrick ; Wannier, Thierry ; Schmidlin, Eric ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E. ; Rouiller, Eric M.

In: The Journal of Comparative Neurology, 2007, vol. 502, no. 4, p. 644 - 659

After injury, regrowth of axons in mammalian adult central nervous system is highly limited. However, in monkeys subjected to unilateral cervical lesion (C7-C8 level), neutralization of an important neurite outgrowth inhibitor, Nogo-A, stimulated axonal sprouting caudal to the lesion, accompanied by enhanced functional recovery of manual dexterity, compared with lesioned monkeys treated with a...

Inter- and Intrahemispheric Dissociations in Ideomotor Apraxia: A Large-Scale Lesion-Symptom Mapping Study in Subacute Brain-Damaged Patients

Manuel, Aurelie L. ; Radman, Narges ; Mesot, Delphine ; Chouiter, Leila ; Clarke, Stephanie ; Annoni, Jean-Marie ; Spierer, Lucas

In: Cerebral Cortex, 2013, vol. 23, no. 12, p. 2781-2789

inter- and intrahemispheric dissociations in ideomotor apraxia : a large-Scale lesion–symptom mapping study in subacute brain-damaged patients

Manuel, Aurelie L. ; Radman, Narges ; Mesot, Delphine ; Chouiter, Leila ; Clarke, Stephanie ; Annoni, Jean-Marie ; Spierer, Lucas

In: Cerebral Cortex, 2012, vol. 23, no. 12, p. 2781-2789

Pantomimes of object use require accurate representations of movements and a selection of the most task-relevant gestures. Prominent models of praxis, corroborated by functional neuroimaging studies, predict a critical role for left parietal cortices in pantomime and advance that these areas store representations of tool use. In contrast, lesion data points to the involvement of left inferior...

Progressive plastic changes in the hand representation of the primary motor cortex parallel incomplete recovery from a unilateral section of the corticospinal tract at cervical level in monkeys

Schmidlin, Eric ; Wannier, Thierry ; Bloch, Jocelyne ; Rouiller, Eric M.

In: Brain Research, 2004, vol. 1017, p. 172-182

After a sub-total hemisection of the cervical cord at level C7/C8 in monkeys, a paralysis of the homolateral hand is rapidly followed by an incomplete recovery of manual dexterity, reaching a plateau after about 40–50 days, whose extent appears related to the size of the lesion. During a few days after the lesion, the hand representation in the contralateral motor cortex disappeared, replaced...

A unilateral section of the corticospinal tract at cervical level in Primate does not lead to measurable cell loss in Motor cortex

Wannier, Thierry. ; Schmidlin, Eric ; Bloch, Jocelyne ; Rouiller, Eric M.

In: Journal of Neurotrauma, 2005, vol. 22(6), p. 703

The effects of a unilateral interruption of the dorsolateral funiculus at cervical level on the survival of neurons in the motor cortex were investigated in macaque monkeys. The lesion was made on the left side at the transition region between the 7th and 8th cervical segments, above the motoneurons controlling hand muscles. As a result, the homolateral hand became paretic,...