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Université de Fribourg

mPer1 and mPer2 mutant mice show regular spatial and contextual learning in standardized tests for hippocampus-dependent learning

Zueger, M. ; Urani, A. ; Chourbaji, S. ; Zacher, C. ; Lipp, H. P. ; Albrecht, Urs ; Spanagel, R. ; Wolfer, D. P. ; Gass, P.

In: Journal of Neural Transmission, 2006, vol. 113(3), p. 347 - 356

Learning and memory, like most physiological processes, seem to be under the control of circadian rhythm. The recently cloned mPer1 and mPer2 genes play an important role in the regulation of the circadian rhythm. In this study, we tested mPer1 and mPer2 mutant mice in two different learning and memory paradigms, a water-maze place navigation task and contextual fear...