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Université de Fribourg

Neonatal stroke in mice causes long-term changes in neuronal notch-2 expression that may contribute to prolonged injury

Albéri, Lavinia ; Chi, Zhikai ; Kadam, Shilpa D. ; Mulholland, Justin D. ; Dawson, Valina L. ; Gaiano, Nicholas ; Comi, Anne M.

In: Stroke, 2010, vol. 41, no. Suppl. 1, p. S64-S71

Background and Purpose: Notch receptors (1–4) are membrane proteins that, on ligand stilumation, release their cytoplasmic domains to serve as transcription factors. Notch-2 promotes proliferation both during development and cancer, but its role in response to ischemic injury is less well understood. The purpose of this study was to understand whether Notch-2 is induced after neonatal stroke...