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Université de Fribourg

Developmental regulation of expression of schizophrenia susceptibility genes in the primate hippocampal formation

Favre, Guillaume ; Banta Lavenex, Pamela A. ; Lavenex, Pierre

In: Translational Psychiatry, 2012, vol. 2, p. e173

The hippocampal formation is essential for normal memory function and is implicated in many neurodevelopmental, neurodegenerative and neuropsychiatric disorders. In particular, abnormalities in hippocampal structure and function have been identified in schizophrenic subjects. Schizophrenia has a strong polygenic component, but the role of numerous susceptibility genes in normal brain development...

Université de Fribourg

Postnatal development of the hippocampal formation: A stereological study in macaque monkeys

Jabès, Adeline ; Banta Lavenex, Pamela A. ; Amaral, 3 David G. ; Lavenex, Pierre

In: The Journal of Comparative Neurology, 2011, p. -

We performed a stereological analysis of neuron number, neuronal soma size, and volume of individual regions and layers of the macaque monkey hippocampal formation during early postnatal development. We found a protracted period of neuron addition in the dentate gyrus throughout the first postnatal year and a concomitant late maturation of the granule cell population and individual dentate gyrus...

Université de Fribourg

Quantitative analysis of postnatal neurogenesis and neuron number in the macaque monkey dentate gyrus

Jabès, Adeline ; Banta Lavenex, Pamela A. ; Amaral, David G. ; Lavenex, Pierre

In: European Journal of Neuroscience, 2010, vol. 31, no. 2, p. 273-285

The dentate gyrus is one of only two regions of the mammalian brain where substantial neurogenesis occurs postnatally. However, detailed quantitative information about the postnatal structural maturation of the primate dentate gyrus is meager. We performed design-based, stereological studies of neuron number and size, and volume of the dentate gyrus layers in rhesus macaque monkeys (Macaca...