Université de Fribourg

Hormonal regulation of the humoral innate immune response in Drosophila melanogaster

Flatt, Thomas ; Heyland, Andreas ; Rus, Florentina ; Porpiglia, Ermelinda ; Sherlock, Chris ; Yamamoto, Rochele ; Garbuzov, Alina ; Palli, Subba R. ; Tatar, Marc ; Silverman, Neal

In: The Journal of Experimental Biology, 2008, vol. 21, no. 1, p. 2712-2724

Juvenile hormone (JH) and 20-hydroxy-ecdysone (20E) are highly versatile hormones, coordinating development, growth, reproduction and aging in insects. Pulses of 20E provide key signals for initiating developmental and physiological transitions, while JH promotes or inhibits these signals in a stage-specific manner. Previous evidence suggests that JH and 20E might modulate innate immunity,...

Université de Fribourg

The cuticle and plant defense to pathogens

Metraux, Jean-Pierre ; Serrano, Mario ; Torres, Martha ; Coluccia, Fania ; L’Haridon, Floriane

In: Frontiers in Plant Science, 2014, vol. 5, p. 274

The cuticle provides a physical barrier against water loss and protects against irradiation, xenobiotics and pathogens. Components of the cuticle are perceived by invading fungi and activate developmental processes during pathogenesis. In addition, cuticle alterations of various types induce a syndrome of reactions that often results in resistance to necrotrophs. This article reviews the current...

Université de Fribourg

Systemic cancer immunotherapy with Toll-like receptor 7 agonists: Timing is everything

Hotz, Christian ; Bourquin, Carole

In: Oncoimmunology, 2012, vol. 1, no. 2, p. 227-228

Toll-like receptor (TLR) 7 agonists represent a promising strategy for the immunotherapy of cancer. We have recently investigated the influence of TLR tolerance on the efficacy of systemic tumor treatment with TLR7 ligands. We propose that considering the kinetics of receptor sensitivity highly improves the outcome of cancer immunotherapy.

Université de Fribourg

TNF-α suppresses the expression of clock genes by interfering with E-box-mediated transcription

Cavadini, Gionata ; Petrzilka, Saskia ; Kohler, Philipp ; Jud, Corinne ; Tobler, Irene

In: Proceedings of the National Academy of Sciences of the United States of America, 2007, vol. 104, no. 31, p. 12843-12848

Production of TNF-α and IL-1 in infectious and autoimmune diseases is associated with fever, fatigue, and sleep disturbances, which are collectively referred to as sickness behavior syndrome. In mice TNF-α and IL-1 increase nonrapid eye movement sleep. Because clock genes regulate the circadian rhythm and thereby locomotor activity and may alter sleep architecture we assessed the influence of...

Université de Fribourg

Signal signature and transcriptome changes of Arabidopsis during pathogen and insect attack

Vos, Martin de ; Oosten, Vivian R. van ; Poecke, Remco M. P. van ; Pelt, Johan A. van ; Pozo, Maria J. ; Mueller, Martin J. ; Buchala, Antony J. ; Métraux, Jean-Pierre ; Loon, L. C. van ; Dicke, Marcel ; Pieterse, Corné M. J.

In: Molecular Plant-Microbe Interactions, 2005, vol. 18, p. 923

Plant defenses against pathogens and insects are regulated differentially by cross-communicating signaling pathways in which salicylic acid (SA), jasmonic acid (JA), and ethylene (ET) play key roles. To understand how plants integrate pathogen- and insect-induced signals into specific defense responses, we monitored the dynamics of SA, JA, and ET signaling in Arabidopsis after attack by a...