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Université de Fribourg

The orbitofrontal cortex projects to the parvafox nucleus of the ventrolateral hypothalamus and to its targets in the ventromedial periaqueductal grey matter

Babalian, Alexandre ; Eichenberger, Simone ; Bilella, Alessandro ; Girard, Franck ; Szabolcsi, Viktoria ; Roccaro, Diana ; Alvarez-Bolado, Gonzalo ; Xu, Chun ; Celio, Marco R.

In: Brain Structure and Function, 2019, vol. 224, no. 1, p. 293–314

Although connections between the orbitofrontal cortex (OFC)—the seat of high cognitive functions—the lateral hypothalamus and the periaqueductal grey (PAG) have been recognized in the past, the precise targets of the descending fibres have not been identified. In the present study, viral tracer-transport experiments revealed neurons of the lateral (LO) and the ventrolateral (VLO) OFC...

Université de Fribourg

Eliminating the VGlut2-dependent glutamatergic transmission of parvalbumin-expressing neurons leads to deficits in locomotion and vocalization, decreased pain sensitivity, and increased dominance

Roccaro-Waldmeyer, Diana M. ; Girard, Franck ; Milani, Daniele ; Vannoni, Elisabetta ; Prétôt, Laurent ; Wolfer, David P. ; Celio, Marco R.

In: Frontiers in Behavioral Neuroscience, 2018, vol. 12, p. -

The calcium-binding protein parvalbumin (PV) is a recognized marker of short-axon GABA-ergic neurons in the cortex and the hippocampus. However in addition, PV is expressed by excitatory, glutamatergic neurons in various areas of the brain and spinal cord. Depending on the location of these neurons, loading of their synaptic vesicles with glutamate is mediated by either of three vesicular...

Université de Fribourg

Parvalbumin-expressing ependymal cells in rostral lateral ventricle wall adhesions contribute to aging-related ventricle stenosis in mice

Filice, Federica ; Celio, Marco R. ; Babalian, Alexandre ; Blum, Walter ; Szabolcsi, Viktoria

In: Journal of Comparative Neurology, 2017, vol. 525, no. 15, p. 3266–3285

Aging-associated ependymal-cell pathologies can manifest as ventricular gliosis, ventricle enlargement, or ventricle stenosis. Ventricle stenosis and fusion of the lateral ventricle (LV) walls is associated with a massive decline of the proliferative capacities of the stem cell niche in the affected subventricular zone (SVZ) in aging mice. We examined the brains of adult C57BL/6 mice and...

Université de Fribourg

Parvalbumin-neurons of the ventrolateral hypothalamic parvafox nucleus receive a glycinergic input: a gene-microarray study

Szabolcsi, Viktoria ; Albisetti, Gioele W. ; Celio, Marco R.

In: Frontiers in Molecular Neuroscience, 2017, vol. 10, p. -

The ventrolateral hypothalamic parvafox (formerly called PV1-Foxb1) nucleus is an anatomical entity of recent discovery and unknown function. With a view to gaining an insight into its putative functional role(s), we conducted a gene-microarray analysis and, armed with the forthcoming data, controlled the results with the Allen databases and the murine BrainStars (B*) database. The parvafox...

Université de Fribourg

The Foxb1‐expressing neurons of the ventrolateral hypothalamic parvafox nucleus project to defensive circuits

Bilella, Alessandro ; Alvarez-Bolado, Gonzalo ; Celio, Marco R.

In: Journal of Comparative Neurology, 2016, vol. 524, no. 15, p. 2955–2981

The parvafox nucleus is an elongated structure that is lodged within the ventrolateral hypothalamus and lies along the optic tract. It comprises axially located parvalbumin (Parv)-positive neurons and a peripheral cuff of Foxb1-expressing ones. In the present study, injections of Cre-dependent adenoviral constructs were targeted to the ventrolateral hypothalamus of Foxb1/Cre mice to label...

Université de Fribourg

Birthdate of parvalbumin-neurons in the Parvafox-nucleus of the lateral hypothalamus

Bilella, Alessandro ; Alvarez-Bolado, Gonzalo ; Celio, Marco R.

In: Brain Research, 2016, vol. 1633, p. 111–114

The Parvafox-nucleus in the lateral hypothalamus is characterized by the presence of two distinct neural populations, the Parvalbumin (Parv) and the Foxb1-expressing ones. Foxb1-neurons are born at day 10 in the subventricular zone of the mouse mammillary region. It would be interesting to know if the subpopulation of Parv- neurons develop independently at different times and then meet the...

Université de Fribourg

Reduction in 50-kHz call-numbers and suppression of tickling-associated positive affective behaviour after lesioning of the lateral hypothalamic parvafox nucleus in rats

Roccaro-Waldmeyer, Diana M. ; Babalian, Alexandre ; Müller, Annelies ; Celio, Marco R.

In: Behavioural Brain Research, 2016, vol. 298, Part B, p. 167–180

The parvafox nucleus is located ventrolaterally in the lateral hypothalamic area (LHA). Its core and shell are composed of neurons expressing the calcium-binding protein parvalbumin (PV) and the transcription factor Foxb1, respectively. Given the known functions of the LHA and that the parvafox nucleus receives afferents from the lateral orbitofrontal cortex and projects to the periaqueductal...

Université de Fribourg

The ventrolateral hypothalamic area and the parvafox nucleus: Role in the expression of (positive) emotions?

Alvarez-Bolado, Gonzalo ; Celio, Marco R.

In: Journal of Comparative Neurology, 2015, p. -

The lateral hypothalamus has been long suspected of triggering the expression of positive emotions, because stimulations of its tuberal portion provoke bursts of laughter. Electrophysiological studies in various species have indeed confirmed that the lateral hypothalamus contributes to reward mechanisms. However, only the rudiments of the neural circuit underlying the expression of positive...