In: Nature Education Knowledge, 2011, vol. 3, no. 3, p. 1-10
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In: Aging, 2010, vol. 2, no. 7, p. 387-389
Dietary restriction (DR), reduced food uptake without malnutrition, is the most universal intervention known to extend animal lifespan, from invertebrates to mammals [1]. However, despite impressive progress in identifying the key components of the DR pathway, many proximal effectors of DR induced longevity remain unknown to date [1]. One central obstacle in the search for such mechanisms is...
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In: Nature Education Knowledge, 2010, vol. 1, no. 12, p. 1-6
This case study highlights the general issues raised earlier. First, that maximum lifespan is not an easily obtainable metric. Specifically, it is unambiguous in the sense that once the last animal dies, it is most definitely dead. But to estimate the variance in maximum lifespan, many replicate populations would need to be followed for each treatment group (with each replicate providing a single...
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In: Journal of Evolutionary Biology, 2007, vol. 20, no. 5, p. 1655-1664
Most animals face periods of food shortage and are thus expected to evolve adaptations enhancing starvation resistance (SR). Most of our knowledge of the genetic and physiological bases of those adaptations, their evolutionary correlates and trade-offs, and patterns of within- and among-population variation, comes from studies on Drosophila. In this review, we attempt to synthesize the...
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