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Evolutionary origin of synapses and neurons – Bridging the gap

Burkhardt, Pawel ; Sprecher, Simon G.

In: BioEssays, 2017/39/10/n/a-n/a

The evolutionary origin of synapses and neurons is an enigmatic subject that inspires much debate. Non-bilaterian metazoans, both with and without neurons and their closest relatives already contain many components of the molecular toolkits for synapse functions. The origin of these components and their assembly into ancient synaptic signaling machineries are particularly important in light...