Université de Fribourg

Life time—circadian clocks, mitochondria and metabolism

Langmesser, Sonja ; Albrecht, Urs

In: Chronobiology International, 2006, vol. 23, no. 1-2, p. 51–157

A functional circadian clock has long been considered a selective advantage. Accumulating evidence shows that the clock coordinates a variety of physiological processes in order to schedule them to the optimal time of day and thus to synchronize metabolism to changes in external conditions. In mitochondria, both metabolic and cellular defense mechanisms are carefully regulated. Abnormal clock...

Université de Fribourg

A guideline for analyzing circadian wheel-running behavior in rodents under different lighting conditions

Jud, Corinne ; Schmutz, Isabelle ; Hampp, Gabriele ; Oster, Henrik ; Albrecht, Urs

In: Biological Procedures Online 2005, 7(1)/101-116/

Most behavioral experiments within circadian research are based on the analysis of locomotor activity. This paper introduces scientists to chronobiology by explaining the basic terminology used within the field. Furthermore, it aims to assist in designing, carrying out, and evaluating wheel-running experiments with rodents, particularly mice. Since light is an easily applicable stimulus that...