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Université de Fribourg

The absence of the calcium-buffering protein calbindin is associated with faster age-related decline in hippocampal metabolism

Moreno, Herman ; Burghardt, Nesha S. ; Vela-Duarte, Daniel ; Masciotti, James ; Hua, Fan ; Fenton, André A. ; Schwaller, Beat ; Small, Scott A.

In: Hippocampus, 2012, vol. 22, p. 1107-1120

Although reductions in the expression of the calcium-buffering proteins calbindin D-28K (CB) and parvalbumin (PV) have been observed in the aging brain, it is unknown whether these changes contribute to age-related hippocampal dysfunction. To address this issue, we measured basal hippocampal metabolism and hippocampal structure across the lifespan of C57BL/6J, calbindin D-28k knockout (CBKO) and...