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The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities

Wider, Diana ; Péli-Gulli, Marie-Pierre ; Briand, Pierre-André ; Tatu, Utpal ; Picard, Didier

In: Molecular and Biochemical Parasitology, 2009, vol. 164, no. 2, p. 147-152

Developing novel drugs against the unicellular parasite Plasmodium is complicated by the paucity of simple screening systems. Heat-shock proteins are an essential class of proteins for the parasite's cyclical life style between different cellular milieus and temperatures. The molecular chaperone Hsp90 assists a large variety of proteins, but its supporting functions for many proteins that are...