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Université de Fribourg

P38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity

Yu, Yi ; Rajapakse, Angana G. ; Montani, Jean-Pierre ; Yang, Zhihong ; Ming, Xiu-Fen

In: Cardiovascular Diabetology, 2014, vol. 13, no. 1, p. 113

Background Endothelial nitric oxide synthase (eNOS)-uncoupling links obesity-associated insulin resistance and type-II diabetes to the increased incidence of cardiovascular disease. Studies have indicated that increased arginase is involved in eNOS-uncoupling through competing with the substrate L-arginine. Given that arginase-II (Arg-II) exerts some of its biological functions through crosstalk...

Université de Fribourg

Impact des ultrasons diffus combinés au travail musculaire sur plaque vibrante sur la modification de la composition corporelle de femmes modérément obèses

Hafiz, S. ; Durrer, D. ; Schutz, Yves

In: Obésité, 2014, p. 1–7

Objectives: To study, in obese subjects, the effect of diffuse ultrasound application in the abdominal area combined to muscular work on a vibrating platform. This dual method aims at accelerating the mobilisation of adipose tissue.Methods: 40 sedentary obese women, 18 to 55 years old, with a BMI ≥30 kg/m2 and ≤40 kg/m2 were randomized into 3 groups. 1) A control group (CONTR, n=13), 2) a...

Université de Fribourg

Comment les régimes amaigrissants font grossir : d’une perspective d’autorégulation de la composition corporelle = How dieting makes some fatter: From a perspective of human body composition autoregulation

Dulloo, Abdul G. ; Jacquet, Jean ; Seydoux, Josiane ; Montani, Jean-Pierre

In: Cahiers de Nutrition et de Diététique, 2013, vol. 48, no. 1, p. 15–25

‘Dieting Makes You Fat’ – the title of a book published in 1983 – embodies the notion that dieting to control body weight, with consequential weight cycling, predisposes the individual to acquire even more body fat. While this notion is controversial, its debate underscores the large gap, which exists in our understanding of basic physiological laws, which govern the regulation of human...

Université de Fribourg

Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA

Yepuri, Gayathri ; Marcelino, Helena ; Shahkhalili, Yasaman ; Aprikian, Olivier ; Macé, Katherine ; Seydoux, Josiane ; Miles, Jennifer L. ; Montani, Jean-Pierre ; Dulloo, Abdul G.

In: British Journal of Nutrition, 2011, vol. 105, p. 1750-1763

The present study investigates whether excessive fat accumulation and hyperinsulinaemia during catch-up growth on high-fat diets are altered by n-6 and n-3 PUFA derived from oils rich in either linoleic acid (LA), α-linolenic acid (ALA), arachidonic acid (AA) or DHA. It has been shown that, compared with food-restricted rats refed a high-fat (lard) diet low in PUFA, those refed...

Université de Fribourg

Thrifty energy metabolism in catch-up growth trajectories to insulin and leptin resistance

Dulloo, Abdul G.

In: Best Practice & Research Clinical Endocrinology & Metabolism, 2008, vol. 22, no. 1, p. 155-171

Catch-up growth early in life (after fetal, neonatal or infantile growth retardation) is a major risk factor for later obesity, type-2 diabetes and cardiovascular diseases. These risks are generally interpreted alongside teleological arguments that environmental exposures which hinder growth early in life lead to programming of ‘thrifty mechanisms’ that are adaptive during the period of...