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J002: Role of the sympathetic nervous system during the development of obesity-induced hypertension in rabbits

Antic, V. ; Kiener-Belforti, F. ; Tempini, A. ; Van Vliet, B.N. ; Montani, J.P.

In: American Journal of Hypertension, 1999, vol. 12, no. S4, p. 205A-205A

Exposure to a high-fat diet alters leptin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits

Prior, Larissa J. ; Eikelis, Nina ; Armitage, James A. ; Davern, Pamela J. ; Burke, Sandra L. ; Montani, Jean-Pierre ; Barzel, Benjamin ; Head, Geoffrey A.

In: Hypertension, 2010, p. -

The activation of the sympathetic nervous system through the central actions of the adipokine leptin has been suggested as a major mechanism by which obesity contributes to the development of hypertension. However, direct evidence for elevated sympathetic activity in obesity has been limited to muscle. The present study examined the renal sympathetic nerve activity and cardiovascular effects of a...

β-Adrenergic control of stearoyl-CoA desaturase 1 repression in relation to sympathoadrenal regulation of thermogenesis

Mainieri, Davide ; Montani, Jean-Pierre ; Seydoux, Josiane ; Giacobino, J. P. ; Boss, O. ; Dulloo, Abdul G.

In: International Journal of Obesity, 2007, vol. 31, no. 2, p. 378–381

Mice lacking β-adrenoceptors, which mediate the thermogenic effects of norepinephrine and epinephrine, show diminished thermogenesis and high susceptibility to obesity, whereas mice lacking stearoyl-CoA desaturase 1 (SCD1), which catalyzes the synthesis of monounsaturated fatty acids, show enhanced thermogenesis and high resistance to obesity. In testing whether β-adrenergic...