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Université de Fribourg

Developmental origin of wiring specificity in the olfactory system of Drosophila

Jefferis, Gregory S. X. E. ; Vyas, Raj M. ; Berdnik, Daniela ; Ramaekers, Ariane ; Stocker, Reinhard F. ; Tanaka, Nobuaki K. ; Ito, Kei ; Luo, Liqun

In: Development, 2004, vol. 131, p. 117-130

In both insects and mammals, olfactory receptor neurons (ORNs) expressing specific olfactory receptors converge their axons onto specific glomeruli, creating a spatial map in the brain. We have previously shown that second order projection neurons (PNs) in Drosophila are prespecified by lineage and birth order to send their dendrites to one of ~50 glomeruli in the antennal lobe. How can a given...