Université de Fribourg

Still Pondering an Age-Old Question

Flatt, Thomas ; Promislow, Daniel E. L.

In: Science, 2007, vol. 318, p. 1255-1256

A theory of trade-offs to explain why we age has spurred 50 years of interdisciplinary research in evolution and molecular genetics.

Université de Fribourg

Diet and longevity in the balance

Flatt, Thomas

In: Nature, 2009, vol. 462, no. 24, p. 989-990

Dietary restriction promotes longevity but impairs fecundity in many organisms. When the amino acids in a diet are fine-tuned, however, lifespan can be increased without loss of fecundity — at least in fruitflies.

Université de Fribourg

Dietary restriction and other lifespan extending pathways converge at the activation of the downstream effector takeout.

Gáliková, Martina

In: Aging, 2010, vol. 2, no. 7, p. 387-389

Dietary restriction (DR), reduced food uptake without malnutrition, is the most universal intervention known to extend animal lifespan, from invertebrates to mammals [1]. However, despite impressive progress in identifying the key components of the DR pathway, many proximal effectors of DR induced longevity remain unknown to date [1]. One central obstacle in the search for such mechanisms is that...

Université de Fribourg

Caffeine induces endothelial tissue factor expression via phosphatidylinositol 3-kinase inhibition

Gebhard, C. ; Holy, E. W. ; Camici, Giovanni G. ; Akhmedov, Alexander ; Stämpfli, S. F. ; Stähli, B. E. ; Rickenbach, B. von ; Breitenstein, A. ; Greutert, Helen ; Yang, Zhihong ; Lüscher, Thomas F. ; Tanner, Felix C.

In: Thrombosis and Haemostasis, 2012, vol. 107, no. 5, p. 803-1007

Tissue factor (TF) is the key activator of coagulation and is involved in acute coronary syndromes. Caffeine is often reported to increase cardiovascular risk; however, its effect on cardiovascular morbidity and mortality is controversial. Hence, this study was designed to investigate the impact of caffeine on endothelial TF expression in vitro . Caffeine concentration-dependently enhanced TF...

Université de Fribourg

Counting calories in Drosophila diet restriction

Min, Kyung-Jin ; Flatt, Thomas ; Kulaots, Indrek ; Tatar, Marc

In: Experimental Gerontology, 2006, vol. 42, no. 3, p. 247-251

The extension of life span by diet restriction in Drosophila has been argued to occur without limiting calories. Here we directly measure the calories assimilated by flies when maintained on full- and restricted-diets. We find that caloric intake is reduced on all diets that extend life span. Flies on low-yeast diet are long-lived and consume about half the calories of flies on high-yeast diets,...