In: Aging Cell, 2007, vol. 6, no. 1, p. 63–71.
Dietary restriction (DR) extends lifespan in an impressively wide array of species spanning three eukaryotic kingdoms. In sharp contrast, relatively little is known about the effects of DR on functional senescence, with most of the work having been done on mice and rats. Here we used Drosophila melanogaster to test the assumption that lifespan extension through DR slows down age-related...
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In: Nature, 2009, vol. 462, no. 24, p. 989-990
Dietary restriction promotes longevity but impairs fecundity in many organisms. When the amino acids in a diet are fine-tuned, however, lifespan can be increased without loss of fecundity — at least in fruitflies.
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In: Aging, 2010, vol. 2, no. 7, p. 387-389
Dietary restriction (DR), reduced food uptake without malnutrition, is the most universal intervention known to extend animal lifespan, from invertebrates to mammals [1]. However, despite impressive progress in identifying the key components of the DR pathway, many proximal effectors of DR induced longevity remain unknown to date [1]. One central obstacle in the search for such mechanisms is...
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In: Evolution, 2009///doi: 10.1111/j.1558-5646.2009.00718.x
Many animal species face periods of chronic nutritional stress where the individuals must continue to develop, grow and/or reproduce despite low quantity or quality of food. Here we use experimental evolution to study adaptation to such chronic nutritional stress in six replicate Drosophila melanogaster populations selected for the ability to survive and develop within a limited time on a very...
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