Université de Fribourg

Neuropeptide F neurons modulate sugar reward during associative olfactory learning of Drosophila larvae

Rohwedder, Astrid ; Selcho, Mareike ; Chassot, Bérénice ; Thum, Andreas S.

In: Journal of Comparative Neurology, 2015, vol. 523, no. 18, p. 2637–2664

All organisms continuously have to adapt their behavior according to changes in the environment in order to survive. Experience-driven changes in behavior are usually mediated and maintained by modifications in signaling within defined brain circuits. Given the simplicity of the larval brain of Drosophila and its experimental accessibility on the genetic and behavioral level, we analyzed if...

Université de Fribourg

Nutritional value–Dependent and nutritional value–Independent effects on Drosophila melanogaster larval behavior

Rohwedder, Astrid ; Pfitzenmaier, Johanna E. ; Ramsperger, Noel ; Apostolopoulou, Anthi A. ; Widmann, Annekathrin ; Thum, Andreas S.

In: Chemical Senses, 2012, vol. 37, no. 8, p. 711-721

Gustatory stimuli allow an organism not only to orient in its environment toward energy-rich food sources to maintain nutrition but also to avoid unpleasant or even poisonous substrates. For both mammals and insects, sugars—perceived as “sweet”—potentially predict nutritional benefit. Interestingly, even Drosophila adult flies are attracted to most high-potency sweeteners preferred by...

Université de Fribourg

Electric shock-induced associative olfactory learning in Drosophila larvae

Pauls, Dennis ; Pfitzenmaier, Johanna E.R. ; Krebs-Wheaton, Rebecca ; Selcho, Mareike ; Stocker, Reinhard F. ; Thum, Andreas S.

In: Chemical Senses, 2010, vol. 35, no. 4, p. 335-346

Associative plasticity is a basic essential attribute of nervous systems. As shown by numerous reports, Drosophila is able to establish simple forms of appetitive and aversive olfactory associations at both larval and adult stages. Whereas most adult studies on aversive learning employed electric shock as a negative reinforcer, larval paradigms essentially utilized gustatory stimuli to...