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Identification and biophysical characterization of a very-long-chain-fatty-acid-substituted phosphatidylinositol in yeast subcellular membranes

Schneiter, Roger ; Brügger, Britta ; Amann, Clare M. ; Prestwich, Glenn D. ; Epand, Raquel F. ; Zellnig, Günther ; Wieland, Felix T. ; Epand, Richard M.

In: Biochemical Journal, 2004, vol. 381, p. 941-949

Morphological analysis of a conditional yeast mutant in acetyl-CoA carboxylase acc1ts/mtr7, the rate-limiting enzyme of fatty acid synthesis, suggested that the synthesis of C₂₆ VLCFAs (very-long-chain fatty acids) is important for maintaining the structure and function of the nuclear membrane. To characterize this C₂₆-dependent pathway in more detail, we have now examined cells that are...