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A genomewide screen reveals a role of mitochondria in anaerobic uptake of sterols in yeast

Reiner, Sonja ; Micolod, Delphine ; Zellnig, Günther ; Schneiter, Roger

In: Molecular Biology of the Cell, 2006, vol. 17, p. 90–103

The mechanisms that govern intracellular transport of sterols in eukaryotic cells are not well understood. Saccharomyces cerevisiae is a facultative anaerobic organism that becomes auxotroph for sterols and unsaturated fatty acids in the absence of oxygen. To identify pathways that are required for uptake and transport of sterols, we performed a systematic screen of the yeast deletion mutant...

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Saccharomyces cerevisiae, a model to study sterol uptake and transport in eukaryotes

Reiner, Sonja ; Micolod, Delphine ; Schneiter, Roger

In: Biochemical Society Transactions, 2005, vol. 33, no. 5, p. 1186-1188

The molecular mechanisms that govern intracellular transport of sterols in eukaryotic cells are only poorly understood. Saccharomyces cerevisiae is a facultative anaerobic organism that requires supplementation with unsaturated fatty acids and sterols to grow in the absence of oxygen, as the synthesis of these lipids requires molecular oxygen. The fact that yeast grows well under anaerobic...

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